RT Journal Article
T1 Exploring and challenging the network of angiogenesis
A1 Montañez, Raúl
A1 Sánchez-Jiménez, Francisca María
A1 Medina, Miguel Ángel
A1 Rodríguez-Quesada, Ana María
K1 Neovascularización
AB Angiogenesis is one of the hallmarks of cancer and, as such, one of the alternative general targets for anticancer therapy. Since angiogenesis is a complex process involving a high number of interconnected components, a network approach would be a convenient systemic way to analyse responses to directed drug attacks. Herein we show that, although the angiogenic network is easily broken by short combinations of directed attacks, it still remains essentially functional by keeping the global patterns and local efficiency essentially unaltered after these attacks. This is a clear sign of its high robustness and resilience and stresses the need of directed, combined attacks for an effective blockade of the process. The results of this theoretical study could be relevant for the design of new antiangiogenic therapies and the selection of their targets.
PB Springer Nature
YR 2011
FD 2011-08-11
LK https://hdl.handle.net/10630/35354
UL https://hdl.handle.net/10630/35354
LA eng
NO Montañez, R., Sánchez-Jiménez, F., Quesada, A. et al. Exploring and challenging the network of angiogenesis. Sci Rep 1, 61 (2011). https://doi.org/10.1038/srep00061
NO Our experimental work is supported by grants PS09/02216 and SAF 2011-26518 (Spanish Ministry of Science and Innovation) and PIE P08-CTS-3759, CVI-6585 and funds from group BIO-267 (Andalusian Government). The “CIBER de Enfermedades Raras” is an initiative from the ISCIII (Spain). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026