RT Journal Article
T1 Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintaining of pregnancy.
A1 Reyes Palomares, Arturo
A1 Lendínez-Ramírez, Ana María
A1 Pérez-Nevot, Beatriz
A1 Cortés-Rodriguez, Miriam
A1 Martínez, Francisco
A1 Garrido, Nicolás
A1 Ruiz-Galdón, Maximiliano
A1 Reyes-Engel, Armando
K1 Polimorfismo genético
K1 Serotonina
K1 Embriones humanos
K1 Embarazo
AB Objective: To explore whether serotonin-related gene polymorphisms influence clinical outcomes of in vitro fertilization (IVF) treatment in recipients using donated oocytes.Design: Nested case-control study.Setting: University-affiliated infertility clinic.Patient(s): Two hundred forty-five women undergoing IVF treatment with donated oocytes.Intervention(s): None.Main Outcome Measure(s): Genotype and haplotype analysis of the serotonin transporter linked polymorphic region (5-HTTLPR), rs1800532, rs6295, rs6313 and rs3813929, between recipients grouped according to the results of the oocyte donation IVF treatment.Result(s): No differences were found between genotype distribution of the Tryptophan hydroxylase 1 (TPH1), serotonin receptor 2A (5-HT2A) and serotonin receptor 2C (5-HT2C) polymorphisms. Recipients carrying LL genotype for 5-HTTLPR suffered lower clinical pregnancy (CP) rates and higher biochemical pregnancy loss (BPL) events. Lower implantation rates (IR) were found in CC carriers for 5-HT1A.rs6295 who also presented higher BPL rates. A lower incidence of CP was observed for LC haplotypes, corresponding to an increase in BPL rates.  Conclusion(s) A strong association was found between early pregnancy loss and recipients carrying the 5 HTTLPR and rs6295 genetic variants. Identifying biological processes involving serotonin and embryo implantation may help to understand the dynamics of the maternal-embryo dialogue.
PB Elsevier SCI LTD
YR 2013
FD 2013-02-13
LK https://hdl.handle.net/10630/37561
UL https://hdl.handle.net/10630/37561
LA eng
NO Palomares, A. R., Lendínez-Ramírez, A. M., Pérez-Nevot, B., Cortés-Rodríguez, M., Martínez, F., Garrido, N., Ruiz-Galdón, M., & Reyes-Engel, A. (2013). Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy. Fertility and Sterility, 99(7), 2009-2016.e2.
NO This work was supported by grant PTQ 09-01-00496.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026