RT Conference Proceedings
T1 WAT alterations in diabetic mice: its connection and implication in ad pathogenesis.
A1 Bettinetti-Luque, Miriam
A1 Trujillo-Estrada, Laura Isabel
A1 Andreo-López, Juana
A1 Cantero-Molina, Francisco
A1 Da Cunha, Celia
A1 Sánchez-Mejías, Elisabeth
A1 LaFerla, Frank
A1 Gutiérrez-Pérez, Antonia
A1 Baglietto-Vargas, David
AB Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onsetand progression. Recent evidences have suggested that metabolic alterations are an important pathological feature indisease progression in AD. Likewise, diabetes and obesity, two mayor metabolic illnesses associated with white adiposetissue expansion, are risk factors for AD. Here, we hypothesize that the white adipose tissue may serve as a key communicator organ between the brain and peripheral metabolic illnesses. We used histological stains,immunohistochemistry and biochemical means to determine changes in the white adipose tissue from WT and db/db mice.Moreover, similar techniques were used in the brain of 3xTg-AD mice that received white fat pads from WT and db/db donors to determine any changes in amyloid and tau pathology. Our study shows that recipient 3xTg-AD mice from db/db fat pads mice develop profound changes in tau pathology due to increased CDK5/p25 expression compared to 3xTg-AD mice thatreceived fad pads from WT mice. This increment in tau level was associated with elevated levels in IL-1β and microglial activation. However, we found that Aβ levels were reduced in recipient 3xTg-AD mice from db/db fat pads compared to 3xTg-AD mice that received fad pads from WT mice. These reduction in Aβ levels were correlated with an increment in microgliaphagocytic capacity. Overall, our study demonstrates a novel important crosstalk between AD and diabetes type II through white adipose cells and a differential effect on tau and Aβ pathology.
YR 2022
FD 2022-07-13
LK https://hdl.handle.net/10630/24853
UL https://hdl.handle.net/10630/24853
LA eng
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 25 ene 2026