RT Journal Article
T1 Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats
A1 Arrabal-Gómez, José Carlos
A1 Rasiel, Beltran-Casanueva
A1 Hernández-García, Aracelis
A1 Bayolo-Guanche, Juan Vicente
A1 Barbancho-Fernández, Miguel Ángel
A1 Serrano-Castro, Pedro Jesús
A1 Narváez, Manuel
K1 Degeneración (Patología)
K1 Sistema nervioso - Degeneración
AB This study investigates the combined effects of the neuropeptide Y Y1 receptor (NPY1R) agonist [Leu31-Pro34]NPY at a dose of 132  g and Ketamine at 10 mg/Kg on cognitive functions and neuronal proliferation, against a backdrop where neurodegenerative diseases present an escalating challenge to global health systems. Utilizing male Sprague-Dawley rats in a physiological model, this research employed a single-dose administration of these compounds and assessed their impact 24 h after treatment on object-in-place memory tasks, alongside cellular proliferation within the dorsal hippocampus dentate gyrus. Methods such as the in situ proximity ligation assay and immunohistochemistry for proliferating a cell nuclear antigen (PCNA) and doublecortin (DCX) were utilized. The results demonstrated that co-administration significantly enhanced memory consolidation and increased neuronal proliferation, specifically neuroblasts, without affecting quiescent neural progenitors and astrocytes. These effects were mediated by the potential formation of NPY1R-TrkB heteroreceptor complexes, as suggested by receptor co-localization studies, although further investigation is required to conclusively prove this interaction. The findings also highlighted the pivotal role of brain-derived neurotrophic factor (BDNF) in mediating these effects. In conclusion, this study presents a promising avenue for enhancing cognitive functions and neuronal proliferation through the synergistic action of the NPY1R agonist and Ketamine, potentially via NPY1R-TrkB heteroreceptor complex formation, offering new insights into therapeutic strategies for neurodegenerative diseases.
YR 2024
FD 2024-04-12
LK https://hdl.handle.net/10630/33369
UL https://hdl.handle.net/10630/33369
LA eng
NO Arrabal-Gómez, C.; Beltran-Casanueva, R.; Hernández-García, A.; Bayolo-Guanche, J.V.; Barbancho-Fernández, M.A.; Serrano-Castro, P.J.; Narváez, M. Enhancing Cognitive Functions and Neuronal Growth through NPY1R Agonist and Ketamine Co-Administration: Evidence for NPY1R-TrkB Heteroreceptor Complexes in Rats. Cells 2024, 13, 669. https://doi.org/10.3390/ cells13080669
NO Financición de UMA18-FEDERJA-100 y ProyExcel_00613, Juntade Andalucía, Spain, to M.N. Financiación para publicar en open access de la Universidad de Málaga/CBUA.También se ha recibido financiación adicional de la Cátedra Imbrain: Neurociencia Integrada y Bionestar to M.N.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026