RT Journal Article
T1 The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain
A1 Maravilla-Herrera, Paulina
A1 Merino, Maria
A1 Alfonso Zamora, Santiago
A1 Balea Filgueiras, Jesús
A1 Carrascosa Carrillo, José Manuel
A1 Delgado Sánchez, Olga
A1 Dolz Sinisterra, Francisco
A1 García-Ruiz, Antonio J.
A1 Herranz Pinto, Pedro
A1 Manfredi, Antonio
A1 Martínez Olmos, José
A1 Morales de los Ríos Luna, Paloma
A1 Puig, Lluís
A1 Ros, Sandra
A1 Hidalgo-Vega, Álvaro
K1 Psoriasis - Tratamiento
K1 Psoriasis - Aspectos sociales
AB Therapeutic advances have made PASI 90 or PASI 100 responses possible in most patients treated with some biologics. A greater response may generate social value beyond clinical outcomes that would benefit both patients and society.Methods: A 1-year economic model was applied to estimate the impact of having a PASI 75, PASI 90, or PASI 100 response in four areas of analysis (quality of life, activities of daily living, work productivity, and out-of-pocket expenditures) and the social value of having a PASI 90 or PASI 100 response in comparison with a PASI 75 response. A mixed-methods approach based on the scientific literature, a focus group with patient, and an advisory committee with psoriasis stakeholders was used. The model included three diferent scenarios: having a PASI 90 vs a PASI 75 response; a PASI 100 vs a PASI 90 response; and a PASI 100 vs a PASI 75 response. A sensitivity analysis was included.Results: The annual economic impact per patient with moderate-to-severe plaque psoriasis having a PASI 75 response was estimated at Ł 6,139, mainly related to labour productivity losses and quality of life reductions. Having a PASI 90 or a PASI 100 response would reduce this impact to e3,956 or e1,353, respectively. Accordingly, the social value of having a PASI 90 instead of a PASI 75 response was estimated at e2,183, and e4,786 with a PASI 100 response.Discussion: A PASI 90 or PASI 100 response would have a lower economic impact and a greater social value than a PASI 75 response for patients with moderate-to-severe plaque psoriasis.
PB Hai Fang, Peking University, China
YR 2023
FD 2023
LK https://hdl.handle.net/10630/30295
UL https://hdl.handle.net/10630/30295
LA eng
NO Maravilla-Herrera P, Merino M, Alfonso Zamora S, Balea Filgueiras J, Carrascosa Carrillo JM, Delgado Sánchez O, Dolz Sinisterra F, García-Ruiz A, Herranz Pinto P, Manfredi A, Martínez Olmos J, Morales de los Ríos Luna P, Puig L, Ros S and Hidalgo-Vega Á (2023) The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain. Front. Public Health 11. doi:10.3389/fpubh.2023.1000776
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026