RT Journal Article
T1 Pancreatic Metastases from Renal Cell Carcinoma. Postoperative Outcome after Surgical Treatment in a Spanish Multicenter Study (PANMEKID)
A1 Blanco-Fernández, Gerardo
A1 Fondevila-Campo, Constantino
A1 Sanjuanbenito, Alfonso
A1 Fabregat-Prous, Joan
A1 Secanella-Medayo, Luís
A1 Rotellar-Sastre, Fernando
A1 Pardo-Sánchez, Fernando
A1 Prieto-Calvo, Mikel
A1 Marín-Ortega, Hector
A1 Sánchez-Cabús, Santiago
A1 Diez-Valladares, Luís
A1 Alonso-Casado, Oscar
A1 González-Serrano, Carmen
A1 Rodríguez-Sanjuan, Juan Carlos
A1 García-Plaza, Gabriel
A1 Jaén-Torrejimeno, Isabel
A1 Suárez-Muñoz, Miguel Angel
A1 Becerra-Massare, Antonio
A1 Senra-Del Rio, Paula
A1 Pando, Elizabeth
A1 López-Andújar, Rafael
A1 Muñoz-Forner, Elena
A1 Rodriguez-López, Mario
A1 Pereira, Fernando
A1 Serrablo-Requejo, Alejandro
A1 Sánchez Turrión, Victor
A1 Jiménez Garrido, Manuel
A1 Burdío, Fernando
A1 Martín-Pérez, Elena
A1 Estevan-Estevan, Rafael
A1 López-Guerra, Diego
A1 Castell-Gómez, José
A1 Salinas-Gómez, Javier
A1 López-Baena, José Ángel
A1 López-Ben, Santiago
A1 Solar-García, Lorena
A1 Pérez-Alonso, Alejandro J
A1 Martínez-Insfran, Luis Alberto
A1 Blas, Juan Luis
A1 Cornejo, Marian
A1 Gutierrez-Calvo, Alberto
A1 Domingo-Del Pozo, Carlos
A1 Ochando-Cerdan, Federico
A1 Muñoz-Bellvís, Luís
A1 Rebollar-Saenz, José
A1 Sánchez-Pérez, Belinda
A1 Jover, José María
A1 Gómez-Bravo, Miguel Angel
A1 Ramia, José M
A1 Rojas-Holguín, Adela
K1 Riñones - Cáncer
K1 Cirugía
K1 Cáncer - Recidiva
K1 Metástasis
AB Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study is to evaluate the short and long-term results of a multicenter series in order to determine the effect of surgical treatment on the prognosis of these patients.Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases, from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical characteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on short and long-term evolution after pancreatic resection were collected.Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metastases' resection was 87.35 months (ICR: 1.51-332.55). Distal pancreatectomy was the most performed technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo greater than IIIa in 14 %). The median follow-up time was 43 months (13-78). Overall survival (OS) rates at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and 5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free interval of less than 10 years (2.05 [1.13-3.72], p 0.02) and a history of previous extrapancreatic metastasis (2.44 [1.22-4.86], p 0.01).Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve higher overall survival and disease-free survival, even if extrapancreatic metastases were previously removed. The existence of intrapancreatic multifocal compromise does not always warrant the performance of a total pancreatectomy in order to improve survival
PB Elselvier
YR 2022
FD 2022
LK https://hdl.handle.net/10630/41295
UL https://hdl.handle.net/10630/41295
LA eng
NO Blanco-Fernández G, Fondevila-Campo C, Sanjuanbenito A, Fabregat-Prous J, Secanella-Medayo L, Rotellar-Sastre F, Pardo-Sánchez F, Prieto-Calvo M, Marín-Ortega H, Sánchez-Cabús S, Diez-Valladares L, Alonso-Casado Ó, González-Serrano C, Rodríguez-Sanjuan JC, García-Plaza G, Jaén-Torrejimeno I, Suárez-Muñoz MÁ, Becerra-Massare A, Rio PS, Pando E, López-Andújar R, Muñoz-Forner E, Rodriguez-López M, Pereira F, Serrablo-Requejo A, Turrión VS, Garrido MJ, Burdío F, Martín-Pérez E, Estevan-Estevan R, López-Guerra D, Castell-Gómez J, Salinas-Gómez J, López-Baena JÁ, López-Ben S, Solar-García L, Pérez-Alonso AJ, Martínez-Insfran LA, Blas JL, Cornejo M, Gutierrez-Calvo A, Pozo CD, Ochando-Cerdan F, Muñoz-Bellvís L, Rebollar-Saenz J, Sánchez B, Jover JM, Gómez-Bravo MÁ, Ramia JM, Rojas-Holguín A. Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID). Eur J Surg Oncol. 2022 Jan;48(1):133-141. doi: 10.1016/j.ejso.2021.08.011. Epub 2021 Aug 11. PMID: 34417061.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026