RT Journal Article
T1 Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients
A1 Clemente-Postigo, María Mercedes
A1 Queipo-Ortuño, María Isabel
A1 Murri, Mora
A1 Boto-Ordóñez, María
A1 Pérez-Martínez, Pablo
A1 Andrés-Lacueva, Cristina
A1 Cardona-Díaz, Fernando
A1 Tinahones-Madueño, Francisco José
K1 Lípidos - Metabolismo - Alteraciones
AB The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, this has not been confirmed in obese patients. To study the relationship between a high-fat diet and bacterial endotoxin, we analyzed postprandial endotoxemia in morbidly obese patients after a fat overload. The endotoxin levels were determined in serum and the chylomicron fraction at baseline and 3 h after a fat overload in 40 morbidly obese patients and their levels related with the degree of insulin resistance and postprandial hypertriglyceridemia. The morbidly obese patients with the highest postprandial hypertriglyceridemia showed a significant increase in lipopolysaccharide (LPS) levels in serum and the chylomicron fraction after the fat overload. Postprandial chylomicron LPS levels correlated positively with the difference between postprandial triglycerides and baseline triglycerides. There were no significant correlations between C-reactive protein (CRP) and LPS levels. The main variables contributing to serum LPS levels after fat overload were baseline and postprandial triglyceride levels but not glucose or insulin resistance. Additionally, superoxide dismutase activity decreased significantly after the fat overload. Postprandial LPS increase after a fat overload is related to postprandial hypertriglyceridemia but not to degree of insulin resistance in morbidly obese patients.
PB American Society for Biochemistry and Molecular Biology
YR 2012
FD 2012
LK https://hdl.handle.net/10630/33993
UL https://hdl.handle.net/10630/33993
LA eng
NO Clemente-Postigo, M. et al. (2012). Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients. Journal of Lipid Research, 53 (5), 973 - 978. DOI 10.1194/jlr.P020909
NO This study was funded by the Fondo de Investigación Sanitaria “Centros de Investigación En Red” (CIBER, CB06/03/0018) of the “Instituto de Salud Carlos III”, FIS PS09/00997, FIS 08/1655 and CP07/00095 of the “Instituto de Salud Carlos III”, Madrid, Spain. SAS 08/325 and SAS 10/0696 Consejería de Salud, Junta de Andalucía. M.C.P. was a recipient of a FPU grant from Educa-tion Ministry, Madrid, Spain [AP2009-4537].
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 24 ene 2026