RT Journal Article
T1 Genomic characterization and transcription analysis of European sea bass (Dicentrarchus labrax) rtp3 genes.
A1 Moreno, Patricia
A1 Gémez-Mata, Juan
A1 Álvarez-Torres, Daniel
A1 García-Rosado, Esther
A1 Béjar-Alvarado, Julia
A1 Alonso-Sánchez, María del Carmen
K1 Agentes antivíricos
K1 Lubinas - Genética
K1 Lubinas - Inmunología
K1 Peces - Inmunología
AB Fish RTP3, belonging to the receptor-transporting protein family, display several functions, including a putative antiviral role as virus-responsive gene. In this work, we have identified and characterized two different European sea bass rtp3 genes. In addition, an in vivo transcription analysis in response to LPS, poly I:C and betanodavirus infection (RGNNV genotype) has been performed. The sequence analysis showed that European sea bass displays two rtp3 genes, X1 and X2, composed of two exons and a single intron (1007-bp and 888-bp long, respectively), located within the ORF sequence. The full-length cDNA is 1969 bp for rtp3 X1, and 1491 bp for rtp3 X2. Several ATTTA motifs have been found in the intron sequence of both genes, whereas rtp3 X1 also contains this motif in both untranslated regions. The transcription analyses revealed significant level of rtp3 X2 mRNA in brain and head kidney after LPS and poly I:C inoculation; however, the induction elicited by RGNNV infection was much higher, suggesting an essential role for this protein in controlling NNV infections
PB Elsevier
YR 2023
FD 2023-10-23
LK https://hdl.handle.net/10630/28133
UL https://hdl.handle.net/10630/28133
LA eng
NO Moreno, P. I., Gémez-Mata, J., Álvarez-Torres, D., García-Rosado, E., Béjar, J., & Alonso, M. C. (2023). Genomic Characterization and transcription analysis of European Sea Bass (Dicentrarchus labrax) RTP3 genes. Molecular Immunology, 163, 243-248. https://doi.org/10.1016/j.molimm.2023.10.009
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026