RT Journal Article
T1 Fishing anti(lymph)angiogenic drugs with zebrafish
A1 García-Caballero, Melissa
A1 Rodríguez-Quesada, Ana María
A1 Medina-Torres, Miguel Ángel
A1 Mari-Beffa, Manuel
K1 Neovascularización
AB Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models.Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph) angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays.
YR 2018
FD 2018-10-19
LK https://hdl.handle.net/10630/16662
UL https://hdl.handle.net/10630/16662
LA eng
NO Our experimental work was supported by grants BIO2014-56092-R (Spanish Ministry of Economy and Competitiveness and FEDER), and PIE P12-CTS-1507,CVI-6585 and funds from group BIO-267 (Andalucian Government and FEDER). CIBER de Enfermedades Raras and CIBER de Bioingenierı´a, Biomateriales y Nanomedicina are initiatives from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 ene 2026