RT Journal Article
T1 Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic
A1 Fernández-Fuertes, Marta
A1 Corma-Gómez, Anaïs
A1 Torres, Eva
A1 Rodriguez-Pineda, Elena
A1 Fuentes-López, Ana
A1 Rincon, Pilar
A1 Fernández, Nieves
A1 García, Federico
A1 Bernal, Samuel
A1 Real-Navarrete, Luis Miguel
A1 Macías, Juan
A1 Pineda, Juan A.
K1 COVID-19
AB Whether people living with HIV (PLWH) are at greater risk of acquiring SARS-CoV-2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we evaluated the incidence of associated factors with and the clinical outcome of SARS-CoV-2 infection in PLWH in Southern Spain. This prospective cohort study included PLWH from a Tertiary University Hospital in Southern Spain. Patients were enrolled in the study if (1) they had attended as outpatients our Unit from 1 August 2019 to 8 February 2020 and (2) had two subsequent evaluations from 9 February 2020 to 4 March 2021. SARS-CoV-2 infections were diagnosed by PCR, antigen detection or serology. Seven hundred and nine PLWH were included in the study. Of them, 55 [7.8%, 95% confidence interval (95% CI) 5.9%-9.9%] patients developed SARS-CoV-2 infection. Between 18 May and 29 November 2020, the rate of seroconversion was 5.3% (95% CI: 3.1%-9.0%) for the general population in the area of Seville and 2.3% (95% CI: 1.3%-2.6%) for PLWH in this study (p = .001). After multivariable analysis, adjusted by age, sex, and risk factors for HIV infection, active tobacco use and CDC stage, active tobacco smoking was the only factor independently associated with lower risk of SARS-Cov-2 infection [Incidence rate ratio: 0.29 (95% CI 0.16-0.55) p < .001]. In conclusion, the incidence of SARS-CoV-2 infection among PLWH in Southern Spain during the ongoing pandemic was lower than that reported for the general population in the same area.
PB Wiley
YR 2021
FD 2021-08-17
LK https://hdl.handle.net/10630/24072
UL https://hdl.handle.net/10630/24072
LA eng
NO Fernandez-Fuertes,M.,Corma-Gomez,A.,Torres,E.,Rodriguez-Pineda,E.,Fuentes-Lopez,A.,Rincon,P.,Fernandez,N.,Garcia,F.,Bernal,S.,Real,L.M.,Macias,J.,&Pineda,J.A.(2021).IncidenceofandfactorsassociatedwithSARS-CoV-2infectionamongpeoplelivingwithHIVinSouthernSpainafteroneyearofpandemic.TransboundaryandEmergingDiseases,1–9.https://doi.org/10.1111/tbed.14293
NO This work was supported in part by the Instituto de Salud CarlosIII (Project ‘PI16/01443’), integrated in the national I+D+i 2013–2016andco-fundedbytheEuropeanUnion(ERDF/ESF,‘Investinginyour future’), by the Spanish Network for AIDS investigation (RIS)(www.red.es/redes/inicio)(RD16/0025/0010,RD16/0025/0040),asapartoftheNacionalI+D+I,ISCIIISubdirecciónGeneraldeEvaluaciónand the European Fund for Development of Regions (FEDER). JuanA.PinedareceivedaresearchextensiongrantfromtheProgramadeIntensificacióndelaActividaddeInvestigacióndelServicioNacionaldeSaludCarlosIII(I3SNS).FedericoGarciareceivedaresearchextensiongrantfromtheProgramadeIntensificacióndelaActividaddeInves-tigacióndelServicioAndaluzdeSalud.AnaïsCorma-GomezreceivedaRíoHortegagrantfromtheInstitutodeSaludCarlosIII(grantnum-ber CM19/00251). Funding for open access charge: Universidad deMálaga/CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026