RT Conference Proceedings
T1 On the balance of D2R-MOR and D4R-MOR in the dorsal and ventral striatum. Putative link to morphine dependence and addiction
A1 Fores-Pons, Ramón
A1 Narváez-Peláez, Manuel
A1 Vasudevan, Lakshmi
A1 Crespo-Ramírez, Minerva
A1 Rivera-Ramírez, Alicia
A1 Pérez de la Mora, Miguel
A1 Stove, Christophe
A1 Fuxe, Kjell
A1 Borroto Escuela, Dasiel Óscar
K1 Morfina - Adicción
K1 Dopamina - Receptores
AB The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS represents a novel integrative molecular mechanism in the plasma membrane of neurons and glial cells. It was proposed that they form the molecular basis for learning and short-and long-term memories. This is also true for drug memories formed during the development of substance use disorders like morphine and cocaine use disorders. Herein, we discuss and propose how an increase in opioid heteroreceptor complexes, containing MOR-DOR, MOR-D4R and MOR-D2R, and their balance with each other and A2AR-D2R complexes in the striatal-pallidal enkephalin positive GABA antireward neurons, may represent markers for development of morphine use disorders. We suggest that increased formation of MOR-DOR complexes takes place in the striatal-pallidal enkephalin positive GABA antireward neurons after chronic morphine treatment in part through recruitment of MOR from the MOR-D2R and/or MOR-D4R complexes due to the possibility that MOR upon morphine treatment can develop a higher affinity for DOR. As a result, increased numbers of D2R monomers/homomers in these neurons become free to interact with the A2ARs found in high densities within such neurons. Increased numbers of A2AR-D2R heteroreceptor complexes are formed and contribute to enhanced firing of these antireward neurons due to loss of inhibitory D2R protomer signaling which finally leads to the development of morphine use disorder. Altogether, we propose that these altered complexes could be pharmacological target to modulate the reward and the development of substance use disorders.
PB 8th Mediterranean Neuroscience Society (MNS)
YR 2022
FD 2022-05-30
LK https://hdl.handle.net/10630/24717
UL https://hdl.handle.net/10630/24717
LA eng
NO Este resumen forma parte de la conferencia invitada (título del resumen) del Symposium S19 - Understanding the role of GPCR heteroreceptor complexes and their adaptor proteins in the neuronal networks of the brain in health and mental disorders
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026