RT Journal Article
T1 Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2
A1 Merchante-Berg, Catharina
A1 Brumós, Javier
A1 Yun, Jeonga
A1 Hu, Qiwen
A1 Spencer, Kristina R
A1 Enríquez, Paul
A1 Binder, Brad M.
A1 Heber, Steffen
A1 Stepanova, Anna
A1 Alonso, José M.
K1 Etileno
K1 Hormonas vegetales
AB The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only recently become technically feasible. Using the well-characterized signaling pathway of the phytohormone ethylene and plant-optimized genome-wide ribosome footprinting, we have uncovered a molecular mechanism linking this hormone's perception to the activation of a gene-specific translational control mechanism. Characterization of one of the targets of this translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response. Furthermore, the 3'UTR of EBF2 is sufficient to confer translational regulation and required for the proper activation of ethylene responses. These findings represent a mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator.
PB ELSEVIER
YR 2015
FD 2015-10-22
LK https://hdl.handle.net/10630/29651
UL https://hdl.handle.net/10630/29651
LA spa
NO Merchante C, Brumos J, Yun J, Hu Q, Spencer KR, Enríquez P, Binder BM, Heber S, Stepanova AN, Alonso JM. Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2. Cell. 2015 Oct 22;163(3):684-97. doi: 10.1016/j.cell.2015.09.036. Epub 2015 Oct 22. PMID: 26496608.
NO This work was supported by NSF grants MCB 1158181 and 0519869 to J.M.A.; MCB 0923727 to J.M.A. and A.N.S.; IOS 1444561 to J.M.A., A.N.S., and S.H.; NCSU-RISF to S.H. and J.M.A.; a Marie Curie COFUND U-Mobility post- doctoral fellowship to C.M. (co-funded by the University of Ma´ laga and the EU 7FP GA N  246550); a postdoctoral fellowship from Ministerio de Educacion2008-2011 to J.B.; and an NSF-REU MCB 06103224 to K.R.S.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 23 ene 2026