RT Journal Article
T1 Fasentin diminishes endothelial cell  proliferation, differentiation and  invasion in a glucose metabolism independent manner
A1 Ocaña, María Carmen
A1 Martínez-Póveda, Beatriz Amparo
A1 Mari-Beffa, Manuel
A1 Quesada, Ana R.
A1 Medina-Torres, Miguel Ángel
K1 Neovascularización
AB The synthetic compound fasentin has been described as a modulator of GLUT-1 and GLUT-4 transporters, thus inhibiting glucose uptake in some cancer cells. endothelial glucose metabolism has been recently connected to angiogenesis and it is now an emerging topic in scientific research. Indeed, certain compounds with a known effect on glucose metabolism have also been shown to inhibit angiogenesis. in this work we tested the capability of fasentin to modulate angiogenesis in vitro and in vivo. We show that fasentin inhibited tube formation in endothelial cells by a mechanism that involves a negative effect on endothelial cell proliferation and invasion, without affecting other steps related to the angiogenic process. However, fasentin barely decreased glucose uptake in human dermal microvascular endothelial cells and the GLUT-1 inhibitor STF-31 failed to inhibit tube formation in these cells. therefore, this modulatory capacity on endothelial cells function exerted by fasentin is most likely independent of a modulation of glucose metabolism. taken together, our results show a novel biological activity of fasentin, which could be evaluated for its utility in cancer and other angiogenesis-dependent diseases.
PB Wiley Online Library
YR 2020
FD 2020
LK https://hdl.handle.net/10630/40161
UL https://hdl.handle.net/10630/40161
LA eng
NO Ocaña, M.C., Martínez-Poveda, B., Marí-Beffa, M. et al. Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner. Sci Rep 10, 6132 (2020). https://doi.org/10.1038/s41598-020-63232-z
NO Ministerio de Educación
NO Junta de Andalucía
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026