RT Journal Article
T1 Sleep in youth with autism spectrum disorders: Systematic review and meta-analysis of subjective and objective studies
A1 Díaz-Román, Amparo
A1 Zhang, Junhua
A1 Delorme, Richard
A1 Beggiato, Anita
A1 Cortese, Samuele
K1 Trastornos del espectro autista
K1 Sueño - Trastornos en adolescentes
AB Background: Sleep problems are common and impairing in individuals with autism spectrum disorders (ASD). Evidence synthesis including both subjective (ie, measured with questionnaires) and objective (ie, quantified with neurophysiological tools) sleep alterations in youth with ASD is currently lacking.Objective: We conducted a systematic review and meta-analysis of subjective and objective studies sleep studies in youth with ASD.Methods: We searched the following electronic databases with no language, date or type of document restriction up to 23 May 2018: PubMed, PsycInfo, Embase+Embase Classic, Ovid Medline and Web of Knowledge. Random-effects models were used. Heterogeneity was assessed with Cochran's Q and I2 statistics. Publication (small studies) bias was assessed with final plots and the Egger's test. Study quality was evaluated with the Newcastle Ottawa Scale. Analyses were conducted using Review Manager and Comprehensive Meta-Analysis. FINDINGS: From a pool of 3359 non-duplicate potentially relevant references, 47 datasets were included in the meta-analyses. Subjective and objective sleep outcome measures were extracted from 37 and 15 studies, respectively. Only five studies were based on comorbidity free, medication-naïve participants. Compared with typically developing controls, youth with ASD significantly differed in 10/14 subjective parameters and in 7/14 objective sleep parameters. The average quality score in the Newcastle-Ottawa Scale was 5.9/9.Discussion and clinical implications: A number of subjective and, to a less extent, objective sleep alterations might characterise youth with ASD, but future studies should assess the impact of pharmacological treatment and psychiatric comorbidities.
PB BMJ
YR 2018
FD 2018-10-25
LK https://hdl.handle.net/10630/46281
UL https://hdl.handle.net/10630/46281
LA eng
NO Díaz-Román, A., Zhang, J., Delorme, R., Beggiato, A., & Cortese, S. (2018). Sleep in youth with autism spectrum disorders: Systematic review and meta-analysis of subjective and objective studies. Evidence-Based Mental Health, 21(4), 146–154. https://doi.org/10.1136/ebmental-2018-300037
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 2 may 2026