RT Journal Article
T1 Plasticity in the Working Memory System: Life Span Changes and Response to Injury
A1 Froudist-Walsh, Sean
A1 López-Barroso, Diana
A1 Torres-Prioris, María José
A1 Croxson, Paula L.
A1 Berthier-Torres, Marcelo Luis
K1 Neuronas - Crecimiento
K1 Neurotransmisores
K1 Neuronas - Plasticidad
AB Working memory acts as a key bridge between perception, long-term memory, and action. Thebrain regions, connections, and neurotransmitters that underlie working memory undergo dramaticplastic changes during the life span, and in response to injury. Early life reliance on deepgray matter structures fades during adolescence as increasing reliance on prefrontal and parietalcortex accompanies the development of executive aspects of working memory. The rise andfall of working memory capacity and executive functions parallels the development and loss ofneurotransmitter function in frontal cortical areas. Of the affected neurotransmitters, dopamine andacetylcholine modulate excitatory-inhibitory circuits that underlie working memory, are importantfor plasticity in the system, and are affected following preterm birth and adult brain injury.Pharmacological interventions to promote recovery of working memory abilities have had limitedsuccess, but hold promise if used in combination with behavioral training and brain stimulation.The intense study of working memory in a range of species, ages and following injuries has ledto better understanding of the intrinsic plasticity mechanisms in the working memory system.The challenge now is to guide these mechanisms to better improve or restore working memoryfunction.
PB Sage
YR 2018
FD 2018-07
LK https://hdl.handle.net/10630/34140
UL https://hdl.handle.net/10630/34140
LA eng
NO Froudist-Walsh S, López-Barroso D, José Torres-Prioris M, Croxson PL, Berthier ML. Plasticity in the Working Memory System: Life Span Changes and Response to Injury. The Neuroscientist. 2018;24(3):261-276. doi:10.1177/1073858417717210
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 14 abr 2026