RT Journal Article
T1 Association between Cardiovascular Health, C-Reactive Protein, and Comorbidities in Spanish Urban-Dwelling Overweight/Obese Hypertensive Patients.
A1 Armas-Padrón, Ana María
A1 Sicilia-Sosvilla, Miriam
A1 Ruiz Esteban, Pedro
A1 Torres, Armando
A1 Hernández-Marrero, Domingo
K1 Presión sanguínea
K1 Sistema cardiovascular - Enfermedades
K1 Obesidad
AB The relationship between poorer cardiovascular health metrics (CVHM) plus low-gradeinflammation (LGI) and hypertension-mediated organ damage (HMOD) and hypertension-relatedcomorbidities (HRC) in hypertensive populations with an overweight/obese (Ow/Ob) hypertensionrelatedphenotype is understudied. We examined the relationship between the CVHM scoreand the presence of LGI and Ow/Ob hypertension-associated phenotype morbidities and mortalityin 243 hypertensive patients from an urban primary care center. We recorded the baselineCVHM score plus clinical data, including hs-C-reactive protein (CRP) and prevalent and incidentHMOD-HRC and death. A total of 26 (10.7%) had a body mass index (BMI) < 25 kg/m2, 95 (31.1%)were overweight (BMI 25–29.9 kg/m2), and 122 (50.2%) were obese (BMI   30 kg/m2). There were264 cases of HMOD-HRC and 9 deaths. Higher hs-CRP levels were observed as BMI increased.Linear regression analysis showed a significant correlation between BMI and hs-CRP, adjusted forconfounders. Additionally, individuals with a higher hs-CRP tertile had a significant increase inBMI. Significantly lower log hs-CRP levels were found as the number of ideal CVHM scores rose.Multivariate binary logistic regression found the risk of HMOD-HRC increased significantly as theideal CVHM scores decreased, and hs-CRP levels also correlated with HMOD-HRC in the wholecohort and in the Ow and Ob subpopulations. These findings highlight the need for early interventiontargeting ideal CVHMs among hypertensive individuals with an Ow/Ob phenotype in order toattenuate the inflammatory state and prevent cardiovascular disease.
PB MDPI
YR 2023
FD 2023-07-13
LK https://hdl.handle.net/10630/32236
UL https://hdl.handle.net/10630/32236
LA eng
NO Armas-Padrón, A. M., Sicilia-Sosvilla, M., Ruiz-Esteban, P., Torres, A., & Hernández, D. (2023). Association between Cardiovascular Health, C-Reactive Protein, and Comorbidities in Spanish Urban-Dwelling Overweight/Obese Hypertensive Patients. Journal Of Cardiovascular Development And Disease, 10(7), 300. https://doi.org/10.3390/jcdd10070300
NO Partial funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026