RT Journal Article
T1 Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells
A1 Navarro-Marchal, Saúl
A1 Griñan-Lisan, Carmen
A1 Entrena, José Manuel
A1 Ruiz-Alcalá, Gloria
A1 Tristán-Manzano, María
A1 Martín, Francisco
A1 Pérez-Victoria, Ignacio
A1 Peula-García, José Manuel
A1 Marchal, Juan Antonio
K1 Nanopartículas
AB The latest trends in cancer research and nanomedicine focus on using nanocarriers to target cancer stem cells (CSCs). Specifically, lipid liquid nanocapsules are usually developed as nanocarriers for lipophilic drug delivery. Here, we developed olive oil liquid NCs (O2LNCs) functionalized by covalent coupling of an anti-CD44-fluorescein isothiocyanate antibody (αCD44). First, O2LNCs are formed by a core of olive oil surrounded by a shell containing phospholipids, a nonionic surfactant, and deoxycholic acid molecules. Then, O2LNCs were coated with an αCD44 antibody (αCD44-O2LNC). The optimization of an αCD44 coating procedure, a complete physicochemical characterization, as well as clear evidence of their efficacy in vitro and in vivo were demonstrated. Our results indicate the high targeted uptake of these αCD44-O2LNCs, and the increased antitumor efficacy (up to four times) of paclitaxel-loaded-αCD44-O2LNC compared to free paclitaxel in pancreatic CSCs (PCSCs). Also, αCD44-O2LNCs were able to selectively target PCSCs in an orthotopic xenotransplant in vivo model.
PB ACS Publications
YR 2021
FD 2021-03
LK https://hdl.handle.net/10630/28848
UL https://hdl.handle.net/10630/28848
LA spa
NO Saúl A. Navarro-Marchal, Carmen Griñán-Lisón, José-Manuel Entrena, Gloria Ruiz-Alcalá, María Tristán-Manzano, Francisco Martin, Ignacio Pérez-Victoria, José Manuel Peula-García, and Juan Antonio Marchal. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules 2021, 22, 4, 1374–1388 ; https://doi.org/10.1021/acs.biomac.0c01546
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026