RT Journal Article
T1 Age related changes in the bone microstructure in patients with femoral neck fractures.
A1 Sánchez-Siles, Juan Manuel
A1 Tamimi-Mariño, Iskandar Ahmad
A1 Rodriguez Gonzalez Cortes, Arthur
A1 Ackerman, Jerome L
A1 González-Quevedo, David
A1 Guerado-Parra, Enrique
A1 García, Angel
A1 Yaghoubi, Farid
A1 Abdallah, Mohamed Nur
A1 Eimar, Hazem
A1 Laurenti, Marco
A1 Al-Subaie, Ahmed
A1 Tamimi, Faleh
K1 Huesos - Envejecimiento
K1 Fracturas
K1 Fémures - Fracturas
AB BackgroundThe objective of this study was to analyze the correlation between various bone structural features and age.Study Design & MethodsA total of 29 consecutive patients who suffered an intracapsular hip fracture and underwent joint replacement surgery between May 2012 and March 2013 were included in this study. A 2 cm × 1 cm Ø cylindrical trabecular bone sample was collected from the femoral heads and preserved in formaldehyde. Bone mineral density (BMD), microarchitecture, organic content and crystallography were analyzed using a Dual-energy X-ray absorptiometry scan, micro-CT scan, and high resolution magic-angle-spinning-nuclear magnetic resonance (MAS-NMR), respectively. Statistical correlations were made using Spearman´s or Pearson´s correlation tests depending on the distribution of the continuous variables.ResultsThe mean patient age was 79.83 ± 9.31 years. A moderate negative correlation was observed between age and the hydrogen content in bone (1H), which is an indirect estimate to quantify the organic matrix (r = −0.512, p = 0.005). No correlations were observed between BMD, trabecular number, trabecular thickness, phosphorous content, apatite crystal size, and age (r = 0.06, p = 0.755; r = −0.008, p = 0.967; r = −0.046, p = 0.812; r = −0.152, p = 0.430, respectively). A weak positive correlation was observed between Charlson´s comorbidity index (CCI) and c-axis of the hydroxiapatite (HA) crystals (r = −0.400, p = 0.035).ConclusionThe femoral head relative protein content progressively decreases with age. BMD was not correlated with other structural bone parameters and age. Patients with higher comorbidity scores had larger HA crystals. The present results suggest that the progressive increase in the hip fracture risk in elderly patients could be partially explained by the lower bone protein content in this age group.
PB Elsevier
YR 2020
FD 2020-02-16
LK https://hdl.handle.net/10630/35974
UL https://hdl.handle.net/10630/35974
LA eng
NO Sanchez-Siles JM, Tamimi-Mariño I, Cortes ARG, Ackerman JL, González-Quevedo D, Guerado E, García A, Yaghoubi F, Abdallah MN, Eimar H, Laurenti M, Al-Subaie A, Tamimi F. Age related changes in the bone microstructure in patients with femoral neck fractures. Injury. 2020 Apr;51 Suppl 1:S12-S18. doi: 10.1016/j.injury.2020.02.014. Epub 2020 Feb 16. PMID: 32115206.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/16944
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 3 feb 2026