RT Journal Article
T1 Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
A1 Baglietto-Vargas, David
A1 Kitazawa, Masashi
A1 Le, Elaine J
A1 Estrada-Hernandez, Tatiana
A1 Rodriguez-Ortiz, Carlos
A1 Medeiros, Rodrigo
A1 Green, Kim N
A1 LaFerla, Frank
K1 Alzheimer, Enfermedad de
K1 Hipocampo (Cerebro)
K1 Experimentación animal
AB Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate the role of endogenous murine tau in a model with both plaques and tangles, we developed a novel transgenic mouse model by crossing 3xTg-AD with mtauKO mice (referred to as 3xTg-AD/mtauKO mice). Therefore, this new model allows us to determine the pathological consequences of the murine tau. Here, we show that 3xTg-AD/mtauKO mice have lower tau loads in both soluble and insoluble fractions, and lower tau hyperphosphorylation level in the soluble fraction relative to 3xTg-AD mice. In the 3xTg-AD model endogenous mouse tau is hyperphosphorylated and significantly co-aggregates with human tau. Despite the deletion of the endogenous tau gene in 3xTg-AD/mtauKO mice, cognitive dysfunction was equivalent to 3xTg-AD mice, as there was no additional impairment on a spatial memory task, and thus despite increased tau phosphorylation, accumulation and NFTs in 3xTg-AD mice no further effects on cognition are seen. These findings provide better understanding about the role of endogenous tau to Alzheimer's disease (AD) pathology and for developing new AD models.
PB Elsevier
YR 2013
FD 2013-10-22
LK https://hdl.handle.net/10630/36869
UL https://hdl.handle.net/10630/36869
LA eng
NO Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014 Feb;62:407-15. doi: 10.1016/j.nbd.2013.10.019. Epub 2013 Oct 29. PMID: 24176788.
NO https://www.sciencedirect.com/journal/neurobiology-of-disease: Neurobiology of Disease is a major international open access journal at the interface between basic and clinical neuroscience.https://openpolicyfinder.jisc.ac.uk/id/publication/11397
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026