RT Journal Article
T1 Oxidative and inflammatory effects of pulmonary rehabilitation in patients with bronchiectasis. A prospective, randomized study.
T2 Efectos oxidativos e inflamatorios de la rehabilitación pulmonar en pacientes con bronquiectasia. Estudio prospectivo aleatorizado.
A1 Olveira-Fuster, Casilda
A1 García-Escobar, Eva
A1 Doña, Esperanza
A1 Palenque-Lobato, Francisco Javier
A1 Porras, Nuria
A1 Dorado, Antonio
A1 Godoy, Ana Maria
A1 Rubio-Martín, Elezahara
A1 Bermúdez Silva, Francisco Javier
A1 Romero-Zerbo, Silvana Yanina
A1 Rojo-Martínez, Gemma
A1 Martín-Valero, Rocío
A1 Abuín-Fernández, José
A1 Olveira-Fuster, Gabriel María
K1 Bronquiectasia - Tratamiento
K1 Insuficiencia respiratoria
AB Background: systemic inflammation and oxidative stress are important factors in the pathogenesis of bronchiectasis. Pulmonary rehabilitation (PR) is recommended for bronchiectasis, but there is no data about its effect on the inflammatory and REDOX status of these patients. Aims: to investigate the effect of PR in non-cystic-fibrosis bronchiectasis (NCFB) patients, and to compare it with the effect of PR plus a hyperproteic oral nutritional supplement (PRS) enriched with beta-hydroxy-beta-methylbutyrate (HMB) on serum inflammatory and oxidative biomarkers. Materials and methods: this was an open randomized, controlled trial. Thirty individuals (65 years old or younger with a body mass index over 18.5, older than 65 years with a body mass index over 20) were recruited from September 2013 to September 2014, and randomly assigned to receive PR or PRS. Total neutrophils, and inflammatory and oxidative biomarker levels were measured at baseline, and then at 3 and 6 months. Results: in the PRS group neutrophil levels were decreased from baseline at 6 months. A significantly different fold change was found between the PR and PRS groups. In the PR group, IL-6 and adiponectin were increased by the end of the study while TNFα levels were decreased from baseline at 6 months. REDOX biomarkers remained stable throughout the study except for 8-isoprostane levels, which were increased from baseline at 6 months in both groups of patients. Conclusions: a PR program induced a pro-oxidative effect accompanied by changes in circulating inflammatory cytokine levels in NCFB patients. Our results would also suggest a possible beneficial effect of the HMB enriched supplement on neutrophil level regulation in these patients. The information provided in this study could be useful for choosing the right therapeutic approach in the management of bronchiectasis.
PB Arán
YR 2020
FD 2020
LK https://hdl.handle.net/10630/35298
UL https://hdl.handle.net/10630/35298
LA eng
NO Olveira C, García-Escobar E, Doña E, Palenque FJ, Porras N, Dorado A, Godoy AM, Rubio-Martín E, Bermúdez-Silva FJ, Romero-Zerbo SY, Rojo-Martínez G, Martín-Valero R, Abuín Fernández J, Olveira G. Oxidative and inflammatory effects of pulmonary rehabilitation in patients with bronchiectasis. A prospective, randomized study. Nutr Hosp 2020;37(1):6-13
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026