RT Conference Proceedings
T1 NG2 cells in an animal model of congenital hydrocephalus
A1 Jiménez-Lara, Antonio Jesús
A1 Ojeda-Pérez, Betsaida
A1 García-Bonilla, María
A1 Ruz-Maldonado, Inmaculada
A1 Mateos-Grondona, Jesús
A1 Rodríguez-Pérez, Luis Manuel
A1 Páez-González, Patricia
K1 Hidrocefalia
AB NG2 cells are considered oligodendrocyte precursor cells (OPC). In pathological conditions, NG2 cells contribute to generate oligodendrocytes and reactive astrocytes. This study has been designed to uncover the role of NG2 cells in congenital hydrocephalus using the hyh mouse model.Materials and methodsBrain sections and whole mount preparations were obtained from embryos and postnatal hyh and control mice. NG2 positive (NG2+) cells were co-labelled with different IHC markers to deepest identification. Additionally, trying to understand reproducibility of our results in different neurodegenerative conditions, same NG2 identification approach was performed using ventricular walls explants from control mice after mechanical induction of astrocyte reaction.ResultsA higher number of NG2+ cells were found in the hyh mice compared to the control mice. In addition, NG2+ cells in the hyh mice showed a higher NG2 antigen content compared to the control mice. In the hyh mouse, colocalization results showed that most of NG2+ cells were identified as OPC cells and pericytes, but never as reactive astrocytes o microglial cells. However, in the same approach performed in neurodegenerative conditions, NG2+ cells were mostly identified as reactive astrocytes.ConclusionsNG2 progenitors appear to be affected in hyh mutant mice giving rise to a different NG2+population which role in hydrocephalus is still unkown.
YR 2017
FD 2017-06-28
LK http://hdl.handle.net/10630/14061
UL http://hdl.handle.net/10630/14061
LA eng
NO Comunicación oral. El resumen no se publica por deseo de los autores
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026