RT Journal Article T1 Recent Advances in Mechanochemical Pretreatment of Lignocellulosic Biomass A1 Pérez-Merchán, Antonio Manuel A1 Rodríguez Carballo, Gabriela A1 Torres-Olea, Benjamín A1 García-Sancho, Cristina A1 Maireles-Torres, Pedro Jesús A1 Mérida-Robles, Josefa María A1 Moreno-Tost, Ramón K1 Mecanoquímica AB Biorefineries are industrial facilities where biomass is converted into chemicals, fuels and energy. The use of lignocellulose as raw material implies the development of pretreatments to reduce its recalcitrant character prior to the processes that lead to the synthesis of the products of interest. These treatments are based on physico-chemical processes where it is necessary to use acids, bases, oxidants, and high pressure and temperature conditions that lead to the depolymerization of lignocellulose at the expense of generating a series of streams that must be treated later or to the production of by-products. In recent years, mechanochemistry is becoming relevant in the design of processes that help in the depolymerization of lignocellulose. These mechanochemical processes are being used in combination with chemicals and/or enzymes, allowing the use of minor loads of reagents or enzymes. In this review, the advances achieved in the use of mechanochemistry for treating lignocellulosic biomass or cellulose will be presented, with special emphasis on how these mechanochemical processes modify the structure of lignocellulose and help subsequent treatments. It will focus on using ball milling or extrusion, ending with a section dedicated to future work needed to implement these technologies at the industrial level. PB IOAP-MPDI YR 2022 FD 2022-08-17 LK https://hdl.handle.net/10630/24820 UL https://hdl.handle.net/10630/24820 LA eng NO Pérez-Merchán AM, Rodríguez-Carballo G, Torres-Olea B, García-Sancho C, Maireles-Torres PJ, Mérida-Robles J, Moreno-Tost R. Recent Advances in Mechanochemical Pretreatment of Lignocellulosic Biomass. Energies. 2022; 15(16):5948. https://doi.org/10.3390/en15165948 NO This research was funded by the Spanish Ministry of Science and Innovation (PID2021-122736OB-C42), FEDER (European Union) funds (PID2021-122736OB-C42, P20-00375, UMA20-FEDERJA88) and B.T.O. acknowledges Ministerio de Universidades for his predoctoral contract. Partial funding for open access charge: Universidad de Málaga DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 19 ene 2026