RT Journal Article
T1 Optical Chemical Biosensors for High Throughput Screening of Drugs
A1 Espinosa Bosh, Maria
A1 Ruiz-Sánchez, Antonio Jesús
A1 Sánchez-Rojas, María Fuensanta
A1 Bosch-Ojeda, Catalina
K1 Biosensores
AB Optical biosensors have been commercially available since the early 1990s, and have been used extensively inmany areas of research in the life sciences. Optical biosensors developed for drug analysis generally exploit the high selectivityof the antigen-antibody and drug-protein interaction. Optical biosensors can be made based on optical diffractionor electro-chemiluminescence. High throughput screening, (HTS) which includes automated preparation of a large numberof samples and then screening of their properties in multi-well plates, improves the efficiency of research in many scientificareas, e.g., catalyst screening, food processing, chemical synthesis, drug discovery, absorption, distribution, metabolism,and excretion and toxicological and cell based screening. The three most common detection techniques used inHTS are UV–VIS absorbance, fluorescence and luminescence. In this review, we summarize some recent trends and developmentsin the construction of optical chemical biosensors used in high throughput screening of drugs. Also, we haveincluded environmental, biological and other medical applications of biosensors
PB Bentham Science Publishers Ltd.
YR 2007
FD 2007
LK https://hdl.handle.net/10630/36964
UL https://hdl.handle.net/10630/36964
LA spa
NO ME Bosch, AJR Sánchez, FS Rojas, CB Ojeda, Optical chemical biosensors for high-throughput screening of drugs. Comb Chem High Throughput Screen 10, 413–432 (2007)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026