RT Conference Proceedings
T1 Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
A1 Flores-Burgess, Antonio
A1 Millón-Peñuela, Carmelo
A1 Puigcerver-Martínez, Araceli
A1 Gago-Calderón, Belén
A1 García-Durán, Laura
A1 Cantero-García, Noelia
A1 Narváez-Bueno, José Ángel
A1 Santín-Núñez, Luis Javier
A1 Fuxe, Kjell
A1 Díaz-Cabiale, Zaida
K1 Psiquiatría biológica
K1 Congresos y conferencias
AB Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased burden both for patients and caregivers, as well as with a higher risk of mortality. Although the underlying mechanisms have not yet been clearly defined in the last decade the importance of the role of neuropeptides, including Galanin (GAL) and the N-terminal fragment GAL(1-15) and/or their receptors in the treatment of stress-related mood disorders is becoming increasingly apparent.  We have described that GAL(1-15) induces strong depression-related and anxiogenic-like effects in rats and these effects were significantly stronger than the ones induced by GAL. The GALR1-GALR2 heteroreceptor complexes in the dorsal hippocampus and dorsal raphe (DR) were involved in these effects and demonstrated also in cellular models.Although several neurotransmitter systems and brain areas have been implicated in depression, the pharmacological treatment of major depression is mainly based on drugs elevating serotonergic (5-HT) activity. Specifically, selective 5-HT reuptake inhibitors (SRRIs) are the most commonly used for treatment of major depression. In particular, Fluoxetine (FLX) is usually chosen for the treatment of symptoms of depressionIn view of these results the purpose of the current study was to assess the ability of GAL(1–15) to modulate the behavioral effects of the 5-HT1AR agonist 8-OH-DPAT and FLX.We have analyzed the effect of GAL (1–15) on the 5-HT1AR agonist 8-OH-DPAT and FLX-mediated responses in a behavioral test of depression.
YR 2019
FD 2019-06-17
LK https://hdl.handle.net/10630/17822
UL https://hdl.handle.net/10630/17822
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This work was supported by SAF2016-79008-P, PSI2017-82604-R (Grant BES-2014-068426).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026