RT Journal Article T1 Impact of Multiple Sclerosis and Its Association with Depression: An Analytical Case-Control Investigation A1 Ruiz-Sánchez, Francisco Javier A1 Martins, Maria do Rosário A1 Soares, Salete A1 Romero-Morales, Carlos A1 López-López, Daniel A1 Gómez-Salgado, Juan A1 Jiménez-Cebrián, Ana María K1 Esclerosis múltiple - Aspectos psicológicos AB Multiple sclerosis (MS) is a neurological, chronic, inflammatory, and progressive disease with musculoskeletal problems and neurodegenerative disorders that causes worsening of the health status of patients. The aim of this study was to determine the level of depression in MS patients compared to a population of healthy subjects. The established sample size was 116 subjects matched with the same age, sex, and body mass index. The subjects were recruited from different multiple sclerosis associations and neurology clinics in different public health areas (case group n = 58) and healthy subjects from the same locality (control group n = 58). The scores and categories of the Beck Depression Inventory (BDI) in its Spanish version were collected. There was a clear statistically significant difference (p < 0.05) in the BDI scores between both groups. As a result, we found that the subjects with MS presented worse results with BDI = 9.52 ± 7.70 points compared to the healthy subjects with a BDI score = 5.03 ± 5.14. Within the BDI categories, there were statistically significant differences (p < 0.001), which were greater for the MS group. Depression is a dangerous factor for MS patients, being a trigger for a poorer quality of life. PB MPDI YR 2022 FD 2022-11-04 LK https://hdl.handle.net/10630/25881 UL https://hdl.handle.net/10630/25881 LA eng NO Ruiz-Sánchez, F.J.; do Rosário Martins, M.; Soares, S.; Romero-Morales, C.; López-López, D.; Gómez-Salgado, J.; Jiménez-Cebrián, A.M. Impact of Multiple Sclerosis and Its Association with Depression: An Analytical Case-Control Investigation. Healthcare 2022, 10, 2218. https://doi.org/10.3390/healthcare10112218 NO Partial funding for open access charge: Universidad de Málaga DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 23 ene 2026