RT Journal Article
T1 Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.
A1 Trujillo-Estrada, Laura Isabel
A1 Nguyen, Cassidy
A1 Da Cunha, Celia
A1 Cai, Lena
A1 Forner, Stefania
A1 Martini, Alessandra C.
A1 Ager, Rahasson
A1 Prieto, Gilberto Aleph
A1 Cotman, Carl
A1 Baglietto-Vargas, David
A1 LaFerla, Frank
K1 Alzheimer, Enfermedad de - Aspectos moleculares
K1 Diabetes - Modelos animales
AB Diabetes mellitus (DM) is one of the most devastating diseases that currently affectsthe aging population. Recent evidence indicates that DM is a risk factor for manybrain disorders, due to its direct effects on cognition. New findings have shown thatthe microtubule‐associated protein tau is pathologically processed in DM; however,it remains unknown whether pathological tau modifications play a central role in thecognitive deficits associated with DM. To address this question, we used a gain‐of‐function and loss‐of‐function approach to modulate tau levels in type 1 diabetes(T1DM) and type 2 diabetes (T2DM) mouse models. Our study demonstrates thattau differentially contributes to cognitive and synaptic deficits induced by DM. Onone hand, overexpressing wild‐type human tau further exacerbates cognitive andsynaptic impairments induced by T1DM, as human tau mice treated under T1DMconditions show robust deficits in learning and memory processes. On the otherhand, neither a reduction nor increase in tau levels affects cognition in T2DM mice.Together, these results shine new light onto the different molecular mechanismsthat underlie the cognitive and synaptic impairments associated with T1DM andT2DM.
PB Wiley
YR 2019
FD 2019-02-27
LK https://hdl.handle.net/10630/32651
UL https://hdl.handle.net/10630/32651
LA eng
NO Trujillo-Estrada L, Nguyen C, da Cunha C, et al. Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. Aging Cell. 2019; 18:e12919. https://doi.org/10.1111/acel.12919
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026