RT Journal Article
T1 Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory.
A1 López-Aranda, Manuel Francisco
A1 López-Téllez, Juan Félix
A1 Navarro-Lobato, Irene
A1 Masmudi-Martín, Mariam
A1 Gutiérrez-Pérez, Antonia
A1 Khan, Zafaruddin
K1 Memoria -  Aspectos fisiológicos
K1 Corteza visual
AB Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of V2 are crucial for the processing of object-recognition memory (ORM). Using the protein regulator of G protein signaling–14 (RGS-14) as a tool, we found that the expression of this protein into layer 6 neurons of rat-brain area V2 promoted the conversion of a normal short-term ORM that normally lasts for 45 minutes into long-term memory detectable even after many months. Furthermore, elimination of the same-layer neurons by means of injection of a selective cytotoxin resulted in the complete loss of normal as well as protein-mediated enhanced ORM.
PB AAAS
YR 2009
FD 2009-07-03
LK https://hdl.handle.net/10630/36680
UL https://hdl.handle.net/10630/36680
LA eng
NO López-Aranda MF, López-Téllez JF, Navarro-Lobato I, Masmudi-Martín M, Gutiérrez A, Khan ZU. Role of layer 6 of V2 visual cortex in object-recognition memory. Science. 2009;325(5936):87-89.
NO https://openpolicyfinder.jisc.ac.uk/id/publication/11114
NO This work was supported financially by Ministerio de Ciencia e Innovacion grant BFU 06-0306 and Junta de Andalucia grant CTS 586/07 to Zafar U. Khan and FIS PI060556 grant to Antonia Gutiérrez. Manuel F. López-Aranda. is the recipient of a CIBERNED contract.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026