RT Journal Article
T1 Dissecting the Brain/Islet Axis in Metabesity
A1 Mellado-Gil, Jose M
A1 Cobo-Vuilleumier, Nadia
A1 Martín-Montalvo, Alejandro
A1 Romero-Zerbo, Silvana Yanina
A1 Diaz Contreras, Irene
A1 Hmadcha, Abdelkrim
A1 Soria, Bernat
A1 Martin Bermudo, Francisco
A1 Reyes, Jose C
A1 Bérmudez-Silva, Francisco Javier
A1 Lorenzo, Petra I
A1 Gauthier, Benoit R
K1 Diabetes
AB The high prevalence of type 2 diabetes mellitus (T2DM), together with the fact that current treatments are only palliative and do not avoid major secondary complications, reveals the need for novel approaches to treat the cause of this disease. Efforts are currently underway to identify therapeutic targets implicated in either the regeneration or re-differentiation of a functional pancreatic islet β-cell mass to restore insulin levels and normoglycemia. However, T2DM is not only caused by failures in β-cells but also by dysfunctions in the central nervous system (CNS), especially in the hypothalamus and brainstem. Herein, we review the physiological contribution of hypothalamic neuronal and glial populations, particularly astrocytes, in the control of the systemic response that regulates blood glucose levels. The glucosensing capacity of hypothalamic astrocytes, together with their regulation by metabolic hormones, highlights the relevance of these cells in the control of glucose homeostasis. Moreover, the critical role of astrocytes in the response to inflammation, a process associated with obesity and T2DM, further emphasizes the importance of these cells as novel targets to stimulate the CNS in response to metabesity (over-nutrition-derived metabolic dysfunctions). We suggest that novel T2DM therapies should aim at stimulating the CNS astrocytic response, as well as recovering the functional pancreatic β-cell mass. Whether or not a common factor expressed in both cell types can be feasibly targeted is also discussed.
PB MDPI
YR 2019
FD 2019
LK https://hdl.handle.net/10630/37470
UL https://hdl.handle.net/10630/37470
LA eng
NO Fuente-Martín, E.; Mellado-Gil, J.M.; Cobo-Vuilleumier, N.; Martín-Montalvo, A.; Romero-Zerbo, S.Y.; Diaz Contreras, I.; Hmadcha, A.; Soria, B.; Martin Bermudo, F.; Reyes, J.C.; et al. Dissecting the Brain/Islet Axis in Metabesity. Genes 2019, 10, 350. https://doi.org/10.3390/genes10050350
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026