RT Journal Article
T1 Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment.
A1 Pinto-Medel, Mª Jesús
A1 Oliver-Martos, Begoña
A1 Urbaneja-Romero, Patricia
A1 Hurtado-Guerrero, Isaac
A1 Ortega-Pinazo, Jesús
A1 Serrano-Castro, Pedro Jesús
A1 Fernández-Fernández, Óscar
A1 Leyva-Fernández, Laura
K1 Esclerosis múltiple - Tratamiento
K1 Metilación
K1 Biología molecular
AB The alteration of DNA methylation patterns are a key component of disease onset and/or progression.Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1)methylation levels, as a surrogate marker of global DNA methylation, between multiple sclerosis(MS) patients and healthy controls. In addition, we assessed the association of LINE-1 methylationwith clinical disease activity in patients treated with IFNbeta (IFNβ). We found that individuals withhigh levels of LINE-1 methylation showed 6-fold increased risk of suffering MS. Additionally, treatedMS patients who bear high LINE-1 methylation levels had an 11-fold increased risk of clinical activity.Moreover, a negative correlation between treatment duration and percentage of LINE-1 methylation,that was statistically significant exclusively in the group of patients without clinical activity, wasobserved. Our data suggest that in MS patients, a slight global DNA hypermethylation occurs that maybe related to the pathophysiology of the disease. In addition, global DNA methylation levels could playa role as a biomarker for the differential clinical response to IFNβ.
PB Nature
YR 2017
FD 2017-08-18
LK https://hdl.handle.net/10630/40852
UL https://hdl.handle.net/10630/40852
LA eng
NO Pinto-Medel MJ, Oliver-Martos B, Urbaneja-Romero P, Hurtado-Guerrero I, Ortega-Pinazo J, Serrano-Castro P, Fernández Ó, Leyva L. Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment. Sci Rep. 2017 Aug 18;7(1):8727. doi: 10.1038/s41598-017-09301-2. PMID: 28821874; PMCID: PMC5562733.
NO Consejeria de Salud de la Junta de Andalucia to MJPM
NO Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía cofinanced by Fondo Europeo de Desarrollo Regional (FEDER) to LL.
NO SAS 111228 & PI-0214-2014 (Consejería de Salud); CTS7670/11 (Consejería de Economía, Innovación, Ciencia y Empleo)
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026