RT Journal Article
T1 Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients
A1 Oliver-Martos, Begoña
A1 Órpez, Teresa
A1 Pinto-Medel, Maria Jesús
A1 Mayorga Mayorga, Cristobalina
A1 García-León, Juan Antonio
A1 Maldonado-Sanchez, Rafael
A1 Suardíaz García, Margarita
A1 Guerrero, Miguel
A1 Luque, Gloria
A1 Leyva-Fernández, Laura
A1 Fernández Fernández, Óscar
K1 Esclerosis múltiple
AB IFNß exerts its activity through the interaction with IFNAR, through activation of the JAK/STAT pathway. We analyzed the changes in IFNAR1, IFNAR2, STAT1, STAT2, Tyk2, JAK1, IRF9 and MxA gene expressions after prolonged IFNß treatment, in isolated mononuclear-cell subpopulations from MS patients, by real time PCR. The effect of IFNß on gene expression differed depending on the subpopulation assessed. The data suggest that CD8+ T cells are the most influenced by prolonged IFNß therapy as IFNAR2, Tyk2, IRF9 and Jak1 expressions were decreased, whereas MxA expression was increased in these cells.
PB Elsevier
YR 2011
FD 2011
LK https://hdl.handle.net/10630/33918
UL https://hdl.handle.net/10630/33918
LA eng
NO Oliver-Martos B, Órpez T, Pinto-Medel MJ, Mayorga C, García-León JA, Maldonado-Sanchez R, Suardíaz M, Guerrero M, Luque G, Leyva L, Fernández O. Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients. J Neuroimmunol. 2011 Jan;230(1-2):153-9. doi: 10.1016/j.jneuroim.2010.10.033. Epub 2010 Nov 24. PMID: 21106255.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026