RT Journal Article
T1 Protocol for an economic evaluation of the randomised controlled trial of culprit lesion only PCI versus immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: CULPRITSHOCK trial
A1 Quayyum, Zahidul
A1 Briggs, Andrew
A1 Robles-Zurita, José Antonio
A1 Oldroyd, Keith
A1 Zeymer, Uwe
A1 Desch, Steffen
A1 de Waha, Suzanne
A1 Thiele, Holger
K1 Infarto de miocardio - Aspectos económicos
AB Introduction Emergency percutaneous coronaryintervention (PCI) of the culprit lesion for patients withacute myocardial infarctions is an accepted practice. Amajority of patients present with multivessel disease withadditional relevant stenoses apart from the culprit lesion.In haemodynamically stable patients, there is increasingevidence from randomised trials to support the practiceof immediate complete revascularisation. However, in thepresence of cardiogenic shock, the optimal managementstrategy for additional non-culprit lesions is unknown. Amulticentre randomised controlled trial, CULPRIT-SHOCK, isexamining whether culprit vessel only PCI with potentiallysubsequent staged revascularisation is more effectivethan immediate multivessel PCI. This paper describes theintended economic evaluation of the trial.Methods and analysis The economic evaluation will beconducted using a pre-trial decision model and withintrialanalysis. The modelling-based analysis will provideexpected costs and health outcomes, and incrementalcost-effectiveness ratio over the lifetime for the cohortof patients included in the trial. The within-trial analysiswill provide estimates of cost per life saved at 30 daysand in 1 year, and estimates of health-related quality oflife. Bootstrapping and cost-effectiveness acceptabilitycurves will be used to address any uncertainty aroundthese estimates. Different types of regression modelswithin a generalised estimating equation frameworkwill be used to examine how the total cost andquality-adjusted life years are explained by patients’characteristics, revascularisation strategy, country andcentre. The cost-effectiveness analysis will be from theperspective of each country’s national health services,where costs will be expressed in euros adjusted forpurchasing power parity.
PB BMJ PUBLISHING GROUP
YR 2017
FD 2017
LK https://hdl.handle.net/10630/37083
UL https://hdl.handle.net/10630/37083
LA eng
NO Quayyum Z, Briggs A, Robles-Zurita J, et al. Protocol for an economic evaluation of the randomised controlled trial of culprit lesion only PCI versus immediate multivessel PCI in acute myocardial infarction complicated by cardiogenic shock: CULPRITSHOCK trial. BMJ Open 2017;7:e014849. doi:10.1136/ bmjopen-2016-014849
NO CULPRIT-SHOCK is a Collaboration Project funded by the European Union under the 7th Framework Programme under grant agreement no 602202).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026