RT Journal Article
T1 Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer
A1 Boughanem Lakhal, Hatim
A1 Cabrera-Mulero, Amanda
A1 Hernández Alonso, Daniel
A1 Clemente-Postigo, María Mercedes
A1 Casanueva, Felipe F.
A1 Tinahones-Madueño, Francisco José
A1 Morcillo Espina, Sonsoles
A1 Crujeiras Martínez, Ana Belén
A1 Macías-González, Manuel
K1 Colon - Cáncer
K1 Recto - Cáncer
AB Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt pathway is mainly regulated by Wnt antagonists, as secreted frizzled-related protein (SFRP) family. Indeed, SFRP2 is proposed as a noninvasive biomarker for CRC diagnosis. Vitamin D also antagonizes Wnt signaling in colon cancers cells. Several studies showed that vitamin D was able to alter DNA methylation, although this mechanism is not yet clear. Therefore, the aim of this study was to find an association between circulating 25-OH vitamin D (30th percentile of vitamin D) and the SFRP2 methylation.
PB Springer Nature
YR 2020
FD 2020
LK https://hdl.handle.net/10630/35698
UL https://hdl.handle.net/10630/35698
LA eng
NO Boughanem, H., Cabrera-Mulero, A., Hernández-Alonso, P. et al. Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer. Clin Epigenet 12, 83 (2020). https://doi.org/10.1186/s13148-020-00875-9
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026