RT Journal Article
T1 Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
A1 Forman, Katherine
A1 Martínez, Fernando
A1 Cifuentes-Rueda, Manuel
A1 Fernández, Marcos
A1 Bertinar, Romina
A1 Torres, Pablo
A1 Salazar, Katherine
A1 Godoy, Alejandro
A1 Nualart, Francisco
K1 Vitamina C - Uso terapéutico
AB Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. Oxidized or reduced vitamin C exerts different actions on tissues and has different metabolism and uptake. In this study, we analyzed the antiaging effect of vitamin C, both oxidized and reduced forms, in renal aging using laser microdissection, quantitative reverse-transcription polymerase chain reaction, and immunohistochemical analyses. In the kidneys of old SAM mice (10 months of age), a model of accelerated senescence, vitamin C, especially in the oxidized form (dehydroascorbic acid [DHA]) improves renal histology and function. Serum creatinine levels and microalbuminuria also decrease after treatment with a decline in azotemia. In addition, sodium-vitamin C cotransporter isoform 1 levels, which were increased during aging, are normalized. In contrast, the pattern of glucose transporter 1 expression is not affected by aging or vitamin C treatment. We conclude that oxidized and reduced vitamin C are potent antiaging therapies and that DHA reverses the kidney damage observed in senescence-accelerated prone mouse 8 to a greater degree.
PB Wiley
YR 2020
FD 2020-12
LK https://hdl.handle.net/10630/36230
UL https://hdl.handle.net/10630/36230
LA eng
NO Forman K, Martínez F, Cifuentes M, Fernández M, Bertinat R, Torres P, Salazar K, Godoy A, Nualart F. Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice. J Cell Physiol. 2020 Dec;235(12):9773-9784. doi: 10.1002/jcp.29791. Epub 2020 May 21. PMID: 32437012.
NO PIA CONICYT. Grant Number: ECM 12Fondecyt regular. Grant Number: 1181243CONICYT REDI. Grant Number: 170373Fondecyt Iniciación. Grant Number: 11160949
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026