RT Journal Article
T1 Treatment and outcome of patients with stage IS testicular cancer: a retrospective study from the Spanish Germ Cell Cancer Group.
A1 Aparicio, Jorge
A1 Sánchez-Muñoz, Alfonso
A1 Ochenduszko, Sebastian
A1 Guma, Josep
A1 Fernández-Aramburo, Antonio
A1 García del Muro, Xavier
A1 Quiroga, Vanesa
A1 Sastre, Javier
A1 Alonso-Gordoa, Teresa
A1 Sagastibelza, Naiara
A1 Maroto, Pablo
A1 Gómez-de-Liaño, Alfonso
A1 Vázquez, Sergio
A1 Diz, P.
A1 Durán, Ignacio
A1 Domenech, Montserrat
A1 Pinto, Álvaro
A1 Hernández, Amaia
A1 González-Billalabeitia, Enrique
A1 Terrasa, Josefa
K1 Testículos - Cáncer - Tratamiento
AB Stage IS testicular cancer is defined by the persistence of elevated serum tumor markers, including α-fetoprotein and/or β-human chorionic gonadotropin, after orchiectomy without radiological evidence of metastatic disease. Current treatment recommendations include cisplatin based chemotherapy up front but the recommendations are based on limited single center series.Results: The elevated prechemotherapy tumor markers were α-fetoprotein in 48% of cases, β-human chorionic gonadotropin in 14%, and α-fetoprotein and β-human chorionic gonadotropin in 38%. Median α-fetoprotein and β-human chorionic gonadotropin values were 71 ng/ml and 80 mIU/ml, respectively. The IGCCCG (International Germ Cell Cancer Collaborative Group) prognostic classification was good in 94% of cases. Mixed nonseminomatous germ cell tumor was found in 78% of cases. Of the patients 103 achieved a complete response to chemotherapy. In 6 patients radiological signs of progressive disease developed during chemotherapy, while 8 experienced relapse after an initial complete response. At a median followup of 108 months 108 patients were alive and disease-free. Five and 10-year disease-free survival rates were 87% and 85%, respectively. The predominance of embryonal carcinoma in the primary tumor was the only factor associated with the probability of needing additional therapy.Stage IS testicular cancer is more commonly associated with elevated α-fetoprotein, an IGCCCG good prognosis and mixed nonseminomatous germ cell tumor. Treatment with cisplatin based chemotherapy leads to cure in most cases. However, a proportion of patients require the integration of additio
PB Lippincott, Williams & Wilkins
YR 2019
FD 2019
LK https://hdl.handle.net/10630/31269
UL https://hdl.handle.net/10630/31269
LA eng
NO Aparicio J, Sánchez-Muñoz A, Ochenduszko S, Gumà J, Fernández-Aramburo A, García Del Muro X, Quiroga V, Sastre J, Alonso-Gordoa T, Sagastibelza N, Maroto P, Gómez de Liaño A, Vázquez S, Diz P, Durán I, Domenech M, Pinto A, Hernández A, González-Billalabeitia E, Terrasa J. Treatment and Outcome of Patients with Stage IS Testicular Cancer: A Retrospective Study from the Spanish Germ Cell Cancer Group. J Urol. 2019 Oct;202(4):742-747. doi: 10.1097/JU.0000000000000366. Epub 2019 Sep 6. PMID: 31163007.
NO La revista ha dado permiso para publicar. Ver correos con fecha 8/05/2024.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026