RT Journal Article
T1 Hyaluronic acid and human/bovine serum albumin shelled nanocapsules: Interaction with mucins and in vitro digestibility of interfacial films.
A1 del Castillo-Santaella, Teresa
A1 Aguilera Garrido, Aixa
A1 Galisteo González, Francisco
A1 Gálvez Ruiz, María José
A1 Molina-Bolívar, José Antonio
A1 Maldonado-Valderrama, Julia
K1 Acido hialurónico
K1 Mucopolisacáridos
AB Liquid lipid nanocapsules are oil droplets surrounded by a protective shell, which enable high load and allowcontrolled delivery of lipophilic compounds. However, their use in food formulations requires analysing theirdigestibility and interaction with mucin. Here, serum albumins and hyaluronic acid shelled olive oil nanocapsulesare analysed to discern differences between human and bovine variants, the latter usually used as modelsystem. Interfacial interaction of albumins and hyaluronic acid reveals that human albumin presents limitedconformational changes upon adsorption, which increase by complexation with the polysaccharide present at theinterface. The latter also promotes hydrophobic interactions with mucin, especially at pH 3 and protects albumininterfacial layer under in vitro gastric digestion. The interfacial unfolding induced in human albumin by hyaluronicacid facilitates in vitro lipolysis while its limited conformational changes provide the largest protectionagainst in vitro lipolysis.
PB Elsevier
YR 2022
FD 2022-07-30
LK https://hdl.handle.net/10630/35463
UL https://hdl.handle.net/10630/35463
LA eng
NO Teresa del Castillo-Santaella, Aixa Aguilera-Garrido, Francisco Galisteo-González, María José Gálvez-Ruiz, José Antonio Molina-Bolívar, Julia Maldonado-Valderrama, Hyaluronic acid and human/bovine serum albumin shelled nanocapsules: Interaction with mucins and in vitro digestibility of interfacial films, Food Chemistry, Volume 383, 2022, 132330, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2022.132330
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026