RT Journal Article
T1 Mucoadhesive properties of liquid lipid nanocapsules enhanced by hyaluronic acid
A1 Aguilera Garrido, Aixa
A1 Molina-Bolívar, José Antonio
A1 Gálvez Ruiz, María José
A1 Galisteo González, Francisco
K1 Ácido hialurónico
AB In the field of drug delivery, nanoparticles (NPs) offer important advantages such as drug protection andsolubilization, increased bioavailability, prolonged blood circulation time or sustained drug delivery.Regarding patients’ quality of life, the oral route is the most convenient, but developing oral therapies is agreat challenge because of the physiological barriers to overcome. NPs can protect the active compoundfrom the digestive process, but they need to diffuse through the mucus layer and be absorbed by theintestinal epithelium. Interaction between NPs and mucus can be promoted by the mucoadhesiveproperties of polysaccharide hyaluronic acid (HA). In this work, the interaction between mucin and liquidlipid nanocapsules loaded with Coumarin 153 and coated with HA of different molecular weights, hasbeen evaluated by dynamic light scattering and by fluorimetric techniques, providing new insights in theinvestigation of this interaction. Hydrodynamic radius and z-potential data evidence that mucin and HAinteract even at low mucin concentrations, and suggest that a layer of mucin is formed around theparticles. FRET analysis, static fluorescence spectroscopy, anisotropy studies and time-resolved fluorescencefurther confirmed this interaction, allowed determination of binding constants and disclosed thedifferent behaviour of low and high molecular weight HA.
PB Elsevier
YR 2019
FD 2019
LK https://hdl.handle.net/10630/35605
UL https://hdl.handle.net/10630/35605
LA eng
NO A. Aguilera-Garrido, J.A. Molina-Bolívar, M.J. Gálvez-Ruiz, F. Galisteo-González, Mucoadhesive properties of liquid lipid nanocapsules enhanced by hyaluronic acid, Journal of Molecular Liquids, Volume 296, 2019, 111965, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2019.111965
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026