RT Dissertation/Thesis
T1 Diferencias en el efecto antioxidante y neuroprotector de hidroxitirosol en la diabetes mellitus experimental respecto a una situación de normoglucemia
A1 Villanueva Torres, Beatriz
K1 Polifenoles
AB The aim of this study is to assess whether the administration of hydroxytyrosol (HT) to diabetic animals exerts a neuroprotective effect on brain damage in a model of hypoxia-reoxygenation. Rats (10 per group) were distributed in five groups: nondiabetic rats, control diabetic rats (DR), DR rats treated two months with 1, 5 or 10 mg/kg/day p.o. HT. At the end of follow-up an experimental model of hypoxia-reoxygenation in brain slices was carried out. DR showed increased cell death, oxidative and nitrosative stress and an increase in brain inflammatory mediators. All these alterations were significantly higher in DR than normoglycemic. HT significantly reduced oxidative and nitrosative stress and brain inflammatory mediators production. Cell death was reduced by 25.9%, 37.5% and 41.0% after the administration of 1, 5 or 10 mg/kg/day. In conclusion we provide the neuroprotective effect of the administration of HT in experimental diabetes.
PB UMA Editorial
YR 2016
FD 2016
LK http://hdl.handle.net/10630/14349
UL http://hdl.handle.net/10630/14349
LA spa
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 26 ene 2026