RT Journal Article
T1 Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion.
A1 Vida-Pol, Yolanda
A1 Collado-Martín, Daniel
A1 Nájera-Albendín, Francisco
A1 Claros-Gil, Silvia
A1 Becerra-Ratia, José
A1 Andrades-Gómez, José Antonio
A1 Pérez-Inestrosa, Ezequiel
K1 Células madre
AB Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications.Adequate scaffolds are necessary for their application in vivo, where interactions between cells and thesurface material are critical. Arginine-glycine-aspartic acid tripeptides (RGD) were conjugated topolyamidoamine (PAMAM) dendrimers and used to pre-treat test surfaces. We demonstrate that pretreatmentwith dendrimer-presented tripeptides efficiently increases MSC adhesion to a polystyrene testsurface, and that treatment effectiveness is related to how tripeptides are presented by the dendrimer tothe cell. We tested both R-G-D–dendrimer and dendrimer–R-G-D arrangements and found the formerto be optimal in terms of surface adhesion.
PB Royal Society of Chemistry
YR 2016
FD 2016-05-17
LK https://hdl.handle.net/10630/33768
UL https://hdl.handle.net/10630/33768
LA eng
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026