RT Conference Proceedings T1 Pairwise and incremental multi-stage alignment of metagenomes: A new proposal A1 Perez-Wohlfeil, Esteban A1 Torreño Tirado, Óscar A1 Trelles-Salazar, Oswaldo Rogelio K1 Genomas AB Traditional comparisons between metagenomes are often performed using reference databases as intermediary templates from which to obtain distance metrics. However, in order to fully exploit the potential of the information contained within metagenomes, it becomes of interest to remove any intermediate agent that is prone to introduce errors or biased results. In this work, we perform an analysis over the state of the art methods and deduce that it is necessary to employ fine-grained methods in order to assess similarity between metagenomes. In addition, we propose our developed method for accurate and fast matching of reads. PB Springer YR 2017 FD 2017 LK http://hdl.handle.net/10630/13566 UL http://hdl.handle.net/10630/13566 LA eng NO Pérez-Wohlfeil E., Torreno O., Trelles O. (2017) Pairwise and Incremental Multi-stage Alignment of Metagenomes: A New Proposal. In: Rojas I., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2017. Lecture Notes in Computer Science, vol 10209. Springer, Cham NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. DS RIUMA. Repositorio Institucional de la Universidad de Málaga RD 21 ene 2026