RT Journal Article
T1 Mathematical Modeling of Polyamine Metabolism in Mammals.
A1 Rodríguez-Caso, Carlos Francisco
A1 Montañez, Raúl
A1 Cascante, Marta
A1 Sánchez-Jiménez, Francisca María
A1 Medina-Torres, Miguel Ángel
K1 Poliaminas - Metabolismo
K1 Cáncer - Investigación
AB Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription,and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, and its deregulation is involved inrelevant processes, such as cancer and neurodegenerative disorders. Great efforts have been made to elucidate the nature ofpolyamine homeostasis, giving rise to relevant information concerning the behavior of the different components of polyaminemetabolism, and a great amount of information has been generated. However, a complex regulation at transcriptional, translational, and metabolic levels as well as the strong relationship between polyamines and essential cell processes make it difficult to discriminate the role of polyamine regulation itself from the whole cell response when an experimental approach is given in vivo. To overcome this limitation, a bottom-up approach to model mathematically metabolic pathways could allow us to elucidate the systemic behavior from individual kinetic and molecular properties. In this paper, we propose a mathematical model of polyamine metabolism from kinetic constants and both metabolite and enzyme levels extracted from bibliographic sources. This model captures the tendencies observed in transgenic mice for the so-called key enzymes of polyamine metabolism, ornithine decarboxylase, S-adenosylmethionine decarboxylase and spermine spermidine N-acetyl transferase. Furthermore, the model shows a relevant role of S-adenosylmethionine and acetyl-CoA availability in polyamine homeostasis, which are not usually considered in systemic experimental studies.
PB Elsevier
YR 2006
FD 2006
LK https://hdl.handle.net/10630/32289
UL https://hdl.handle.net/10630/32289
LA eng
NO Andalusian Government Grants SAF2005-01812 and funds to group CVI-267 and to the “Amine System Project” (CVI-657) Ministerio de Ciencia y Tecnología, Spain, Grant SAF2005-01627 (to M. C.). The costs of publication of this article were defrayed in part by the payment of page charges.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 22 ene 2026