RT Journal Article
T1 miR-21 mimic blocks obesity in mice: A novel therapeutic option.
A1 Lhamyani, Said
A1 Gentile, Adriana Mariel
A1 Giráldez-Pérez, Rosa María
A1 Feijóo Cuaresma, Mónica
A1 Romero-Zerbo, Silvana Yanina
A1 Clemente-Postigo, María Mercedes
A1 Zayed, Hatem
A1 Oliva-Olivera, Wilfredo
A1 Bermúdez-Silva, Francisco Javier
A1 Salas-Millán, Manuel Julián
A1 López-Gómez, Carlos
A1 Hmadcha, Abdelkrim
A1 Hajji, Nabil
A1 Olveira-Fuster, Gabriel María
A1 Tinahones-Madueño, Francisco José
A1 El-Bekay, Rajaa
K1 Obesidad
K1 Metabolismo - Alteraciones
K1 Tejido adiposo
K1 Diabetes
AB MicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders. Recently, miRNA mimics are providing a unique mechanism of action that guides the process for drug development and sets out the context of their therapeutic application. miRNA (miR)-21 expression in white adipose tissue (WAT) has been associated with obesity. We aimed to analyze miR-21 expression levels in relation to diabetes and obesity to determine the effect that miR-21 mimic has on processes involved in WAT functionality, to dissect the underlying molecular mechanisms, and to study the potential therapeutic application of the miR-21 mimic against obesity. We found higher miR-21 levels in WAT from non-diabetic obese compared to normoweight humans and mice. Moreover, in 3T3-L1 adipocytes, miR-21 mimic affect genes involved in WAT functionality regulation and significantly increase the expression of genes involved in browning and thermogenesis. Interestingly, in vivo treatment with the miR-21 mimic blocked weight gain induced by a high-fat diet in obese mice, without modifying food intake or physical activity. This was associated with metabolic enhancement, WAT browning, and brown adipose tissue (AT) thermogenic programming through vascular endothelial growth factor A (VEGF-A), p53, and transforming growth factor β1 (TGF-β1) signaling pathways. Our findings suggest that miR-21 mimic-based therapy may provide a new opportunity to therapeutically manage obesity and consequently, its associated alterations.
PB Cell Press
YR 2021
FD 2021
LK https://hdl.handle.net/10630/40703
UL https://hdl.handle.net/10630/40703
LA eng
NO Mol Ther Nucleic Acids. 2021 Jul 2;26:401-416
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026