RT Journal Article
T1 Aggregate-Depleted Brain Fails to Induce Ab Deposition in a Mouse Model of Alzheimer’s Disease.
T2 Inhibition of Amyloid Induction
A1 Duran-Aniotz, Claudia
A1 Morales, Rodrigo
A1 Moreno-González, Inés
A1 Hu, Ping Ping
A1 Fedynyshyn, Joseph
A1 Soto, Claudio
K1 Alzheimer, Enfermedad de
K1 Modelos animales en investigación
AB Recent studies in animal models of Alzheimer’s disease (AD) show that amyloid-beta (Ab) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this study was to analyze whether depletion of aggregates from an AD brain suppresses its in vivo ‘‘seeding’’ capability. Removal of aggregates was performed by using the Aggregate Specific Reagent 1 (ASR1) compound which has been previously described to specifically bind misfolded species. Our results show that pre-treatment with ASR1-coupled magnetic beads reduces the in vivo misfolding inducing capability of an AD brain extract. These findings shed light respect to the active principle responsible for the prion-like spreading of Alzheimer’s amyloid pathology and open the possibility of using seeds-capturing reagents as a promising target for AD treatment.
PB PLOS
YR 2014
FD 2014-02-12
LK https://hdl.handle.net/10630/36989
UL https://hdl.handle.net/10630/36989
LA eng
NO Duran-Aniotz C, Morales R, Moreno-Gonzalez I, Hu PP, Fedynyshyn J, Soto C (2014) Aggregate-Depleted Brain Fails to Induce Aβ Deposition in a Mouse Model of Alzheimer's Disease. PLoS ONE 9(2): e89014. https://doi.org/10.1371/journal.pone.0089014
NO This work was funded by a grant from Novartis Vaccines and Diagnostics to CS and a grant from the Alzheimer’s Association (MNIRGD-12-243075) toRM.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 23 ene 2026