RT Conference Proceedings
T1 Study of the impact of m6A RNA methylation in altered molecular mechanisms in colorectal cancer and its association with obesity
A1 Rego, Alejandro
A1 Pilo, Jesús
A1 García-Flores, Libia Alejandra
A1 Boughanem Lakhal, Hatim
A1 Martín Nuñez, Gracia Maria
A1 Macías-González, Manuel
K1 Cáncer - Etiología
K1 Carcinogénesis
AB Although the etiology of colorectal cancer (CRC) is multifactorial and complex, due to the interaction of altered environmental and genetic mechanisms, obesity is considered a crucial risk factor in the initiation and progression of CRC. Alterations in epigenetic mechanisms, such as changes in the methylation pattern of certain genes, have been shown to have a clear effect on tumorigenesis and progression. In recent years, mounting evidence has revealed that the RNA modification machinery is often altered in human cancers, highlighting their enormous potential as drug targets or markers for diagnosis and early detection in obese subjects.Our objective was to identify in circulating leukocytes alterations in the epi-transcriptomic profile (m6A) of circulating leukocytes and their association with dysregulation of the RNA splicing machinery and alterations of the inflammatory response in patients with obesity-associated CRC.The study revealed significant differences in m6A RNA methylation of circulating leukocytes both between CRC patients and healthy overweight or obese patients, as well as between CRC patients with different BMI. It was also observed that obesity in CRC causes alterations in the expression of spliceosome components and factors related to RNA splicing and genes related to the inflammasome and inflammatory response in circulating leukocytes.Obesity in CRC is associated with alterations in the epitranscriptomic profile (m6A) in circulating leukocytes, in addition to alterations in the gene expression of the splicing machinery and inflammatory regulation.
YR 2023
FD 2023-12-01
LK https://hdl.handle.net/10630/30095
UL https://hdl.handle.net/10630/30095
LA eng
NO Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 2 mar 2026