RT Journal Article
T1 The emergent role of mitochondrial RNA modifications in metabolic alterations
A1 Boughanem Lakhal, Hatim
A1 Böttcher, Yvonne
A1 Tomé-Carneiro, João
A1 López de las Hazas, María-Carmen
A1 Dávalos, Akin Cayir
A1 Macías-González, Manuel
K1 Metabolismo
AB Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial evidence indicates that they play a critical role in accurate protein synthesis. Recent evidence supported those modifications in mitochondrial RNAs also have crucial implications in mitochondrial-related diseases. In the light of current knowledge about the involvement, the association between mitochondrial RNA modifications and diseases arises from studies focusing on mutations in both mitochondrial and nuclear DNA genes encoding enzymes involved in such modifications. Here, we review the current evidence available for mitochondrial RNA modifications and their role in metabolic disorders, and we also explore the possibility of using them as promising targets for prevention and early detection. Finally, we discuss future directions of mitochondrial epitranscriptomics in these metabolic alterations, and how these RNA modifications may offer a new diagnostic and theragnostic avenue for preventive purposes.
PB Wiley
YR 2022
FD 2022-07-25
LK https://hdl.handle.net/10630/24828
UL https://hdl.handle.net/10630/24828
LA spa
NO Boughanem, H., Böttcher, Y., Tomé-Carneiro, J., López de las Hazas, M.-C., Dávalos, A., Cayir, A., & Macias-González, M. (2022). The emergent role of mitochondrial RNA modifications in metabolic alterations. WIREs RNA, e1753. https://doi.org/10.1002/wrna.1753
NO This work was supported by the European Cooperation in Science and Technology (COST) Action CA16120 (European Epitranscriptomic Network). This work was also supported by “Centros de Investigación En Red” (CIBER, CB06/03/0018) of the “Instituto de Salud Carlos III” (ISCIII) (PI18/01399), and co-financed by the European Regional Development Fund (FEDER). This work was also supported by the Agencia Estatal de Investigación and European FEDER Funds (PID2019-109369RB-100 and AGL2018-78922-R). HB is supported by a predoctoral fellowship (“Plan Propio IBIMA 2020 A.1 Contratos predoctorales”, Ref.: predoc20_002). M.M.G. was the recipient of the Nicolas Monardes Programme from the “Servicio Andaluz de Salud, Junta de Andalucia”, Spain (RC-0001-2018 and C-0029-2014). funding for open access charge: Universidad de Málaga
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 11 abr 2026