RT Journal Article
T1 Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease.
A1 Flores-López, María
A1 García-Marchena, Nuria
A1 Pavón-Morón, Francisco Javier
A1 Lara, Estrella
A1 Porras-Perales, Oscar
A1 Araos, Pedro
A1 Requena-Ocaña, Nerea
A1 Torres-Galván, Sandra
A1 Mañas-Padilla, María del Carmen
A1 Rubio, Gabriel
A1 Suárez-Pérez, Juan
A1 Santín-Núñez, Luis Javier
A1 Rodriguez-de-Fonseca, Fernando
A1 Castilla-Ortega, María Estela
A1 García-Fernández, María Inmaculada
A1 Serrano, Antonia
K1 Hígado - Enfermedades
K1 Alcoholismo
AB Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that is synthesized by the enzyme autotaxin (ATX). The ATX-LPA axis has been associated with cognitive dysfunction and inflammatory diseases, mainly in a range of nonalcoholic liver diseases. Recently, preclinical and clinical evidence has suggested a role of LPA signaling in alcohol use disorder (AUD) and AUD-related cognitive function. However, the ATX-LPA axis has not been sufficiently investigated in alcoholic liver diseases. An exploratory study was conducted in 136 participants, 66 abstinent patients with AUD seeking treatment for alcohol (alcohol group), and 70 healthy control subjects (control group). The alcohol group was divided according to the presence of comorbid liver diseases (i.e., fatty liver/steatosis, alcoholic steatohepatitis, or cirrhosis). All participants were clinically evaluated, and plasma concentrations of total LPA and ATX were measured using enzyme-linked immunosorbent assays. Data were primarily analyzed using analysis of covariance (ANCOVA) while controlling for age, body mass index, and sex. Logistic regression models were created to assess the association of the ATX-LPA axis and AUD or liver disease. LPA and ATX were log10-transformed to fit the assumptions of parametric testing.The main results were as follows: total LPA and ATX concentrations were dysregulated in the alcohol group, and patients with AUD had significantly lower LPA (F(1,131) = 10.677, p = 0.001) and higher ATX (F(1,131) = 8.327, p = 0.005) concentrations than control subjects; patients with AUD and liver disease had significantly higher ATX concentrations (post hoc test, p < 0.05) than patients with AUD but not liver disease; significant correlations between AUD-related variables and concentrations of LPA and ATX were only found in the non-liver disease subgroup (the duration of alcohol abstinence with LPA and ATX (r = +0.33, p < 0.05).
YR 2021
FD 2021-09-13
LK https://hdl.handle.net/10630/28786
UL https://hdl.handle.net/10630/28786
LA eng
NO Flores-López, M., García-Marchena, N., Pavon, F. J., Lara, E., Porras-Perales, O., Araos, P., ... & Serrano, A. (2021). Plasma concentrations of lysophosphatidic acid and autotaxin in abstinent patients with alcohol use disorder and comorbid liver disease. Biomedicines, 9(9), 1207.
NO Instituto de Investigación Biomédica de Málaga-IBIMA, 29071 Málaga, Spain.Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Facultad de Psicología, Universidad de Málaga, 29071 Málaga, Spain.Unidad de Adicciones-Servicio de Medicina Interna, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), 08916 Badalona, Spain.Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen de la Victoria de Málaga, 29010 Málaga, Spain.Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.Departamento de Fisiología Humana, Histología Humana, Anatomía Patológica Y Educación Física y Deportiva, Facultad de Medicina, Universidad de Málaga, 29071 Málaga, Spain.Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.Departamento Anatomía Humana, Medicina Legal e Historia de la Ciencia, Facultad de Medicina, Universidad de Málaga, 29071 Málaga, Spain.Partial funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026