RT Journal Article
T1 Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling
A1 Garcia Diaz, Beatriz
A1 Bachelin, Corinne
A1 Coulpier, Fanny
A1 Gerschenfeld, Gaspar
A1 Deboux, Cyrille
A1 Zujovic, Violetta
A1 Charnay, Patrick
A1 Topilko, Piotr
A1 Baron Van Evercooren, Anne
K1 Sistema nervioso central
AB Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invadethe CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo afterexogenous transplantation in the demyelinated spinal cord. The data highlight for the frst time that SC migrate preferentiallyalong blood vessels in perivascular extracellular matrix (ECM), avoiding CNS myelin. We demonstrate in vitro and in vivothat this migration route occurs by virtue of a dual mode of action of Eph/ephrin signaling. Indeed, EphrinB3, enriched inmyelin, interacts with SC Eph receptors, to drive SC away from CNS myelin, and triggers their preferential adhesion to ECMcomponents, such as fbronectin via integrinβ1 interactions. This complex interplay enhances SC migration along the bloodvessel network and together with lesion-induced vascular remodeling facilitates their timely invasion of the lesion site. Thesenovel fndings elucidate the mechanism by which SC invade and contribute to spinal cord repair.
PB Springer Link
YR 2019
FD 2019
LK https://hdl.handle.net/10630/32322
UL https://hdl.handle.net/10630/32322
LA eng
NO Garcia-Diaz, B., Bachelin, C., Coulpier, F. et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol 138, 457–476 (2019). https://doi.org/10.1007/s00401-019-02011-1
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 21 ene 2026