RT Journal Article
T1 A Census of Human Methionine-Rich Prion-like Domain-Containing Proteins
A1 Aledo-Ramos, Juan Carlos
K1 Aminoácidos
K1 Señalización celular
AB Abstract: Methionine-rich prion-like proteins can regulate liquid–liquid phase separation processesin response to stresses. To date, however, very few proteins have been identified as methionine-richprion-like. Herein, we have performed a computational survey of the human proteome to search formethionine-rich prion-like domains. We present a census of 51 manually curated methionine-richprion-like proteins. Our results show that these proteins tend to be modular in nature, with molecularsizes significantly greater than those we would expect due to random sampling effects. Theseproteins also exhibit a remarkably high degree of spatial compaction when compared to averagehuman proteins, even when protein size is accounted for. Computational evidence suggests thatsuch a high degree of compactness might be due to the aggregation of methionine residues, pointingto a potential redox regulation of compactness. Gene ontology and network analyses, performedto shed light on the biological processes in which these proteins might participate, indicate thatmethionine-rich and non-methionine-rich prion-like proteins share gene ontology terms related tothe regulation of transcription and translation but, more interestingly, these analyses also reveal thatproteins from the methionine-rich group tend to share more gene ontology terms among them thanthey do with their non-methionine-rich prion-like counterparts.
PB MDPI
YR 2022
FD 2022-06-29
LK https://hdl.handle.net/10630/40142
UL https://hdl.handle.net/10630/40142
LA eng
NO Aledo, J.C. A Census of Human Methionine-Rich Prion-like Domain-Containing Proteins. Antioxidants 2022, 11, 1289. https://doi.org/10.3390/antiox11071289
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 20 ene 2026