RT Journal Article
T1 Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis
A1 Vega-Núñez, Amanda
A1 Gómez-Sánchez-Lafuente, Carlos
A1 Mayoral Cleries, Fermín
A1 Bordallo Aragón, Antonio
A1 Rodriguez-de-Fonseca, Fernando
A1 Suárez-Pérez, Juan
K1 Depresión mental
AB Bipolar disorder (BD) is a multifactorial chronic psychiatric disease highly defined by genetic, clinical, environmental and social risk factors. The present systematic review and meta-analysis aimed to examine the relationship between inflammatory and neurotrophic factors and clinical, social and environmental factors involved in the development and the characterization of BD. Web of Science, PubMed, PsycINFO, Scopus and Science Direct were searched by two independent reviewers. The systematic review was registered in PROSPERO (CRD42020180626). A total of 51 studies with 4547 patients with a diagnosis of BD were selected for systematic review. Among them, 18 articles were included for meta-analysis. The study found some evidence of associations between BDNF and/or inflammatory factors and different stressors and functional and cognitive impairment, but limitations prevented firm conclusions. The main finding of the meta-analysis was a negative correlation between circulating levels of BDNF and depression severity score (standardized mean difference = −0.22, Confidence Interval 95% = −0.38, −0.05, p = 0.01). Evidence indicates that BDNF has a role in the depressive component of BD. However, the poor consistency found for other inflammatory mediators clearly indicates that highly controlled studies are needed to identity precise biomarkers of this disorder.
PB IOAP-MPDI
YR 2022
FD 2022-06-09
LK https://hdl.handle.net/10630/24688
UL https://hdl.handle.net/10630/24688
LA eng
NO Vega-Núñez A, Gómez-Sánchez-Lafuente C, Mayoral-Cleries F, Bordallo A, Rodríguez de Fonseca F, Suárez J, Guzmán-Parra J. Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis. Biomedicines. 2022; 10(6):1368. https://doi.org/10.3390/biomedicines10061368
NO This research was funded by Atención Primaria, Cronicidad y Promoción de la Salud:Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III(ISCIII), Ministerio de Ciencia e Innovación and European Regional Development Funds-EuropeanUnion (ERDF-EU), grant number RD21/0009/0003; ISCIII, ERDF-EU, grant number PI19/01577;Ministerio de Sanidad, Delegación de Gobierno para el Plan Nacional sobre Drogas, grant numbersPND 2019/040; and Consejería de Salud y Familia, Junta de Andalucía, grant numbers RIC-0111-2019.AV-N (CM19/00025) and CG-S-L (CM19/00240) hold “Rio Hortega” research contracts from theNational System of Health, ISCIII, ERDF-EU. FM-C and JG-P has received funding from the AndalusiaGovernment in the grants for human resources reinforcement in the research activity (Acción A deintensificación 2019 and Acción B de refuerzos de larga duración 2014). The funding sources hadno further role in study design; in the collection, analysis and interpretation of data; in writing ofthe report; and in the decision to submit the paper for publication. Funding for open access charge:Universidad de Málaga/CBUA.
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 4 mar 2026