RT Journal Article
T1 Placenta-derived biomaterials vs. standard care in chronic diabetic foot ulcer healing: A systematic review and meta-analysis
A1 Ruiz-Muñoz, María
A1 Martínez-Barrios, Francisco-Javier
A1 Lópezosa-Reca, Eva
K1 Placenta
K1 Diabetes - Complicaciones y secuelas
AB MethodsThe systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing. The risk of bias assessment was conducted using the tool recommended by the Cochrane Collaboration. Statistical analysis included the individual and combined result of the studies, heterogeneity test, the effect size, sensitivity analysis, and publication bias tests.ResultsTwelve randomized controlled trials (RCTs) with a total of 833 patients were included in this study. This meta-analysis showed a higher rate of complete ulcer healing in groups receiving placenta-derived biomaterials therapies (OR = 6.247 [4.425, 8.819], p < 0.01, I2 = 41 %) compared to control groups.ConclusionPlacenta-derived biomaterials therapies have been shown to be more effective for achieving complete ulcer healing compared to current conventional treatments in DFU.Implications for clinical practiceThe utilization of placenta-derived biomaterials in therapies for wound healing, particularly in chronic DFU, presents promising implications for clinical practice. These biomaterials offer a rich source of growth factors, cytokines, and extracellular matrix components, which can stimulate tissue regeneration and angiogenesis. Incorporating such therapies into clinical practice holds the potential to accelerate wound closure, reduce infection rates, and improve overall healing outcomes in people with diabetic chronic foot ulcers. Furthermore, the availability of these biomaterials can offer clinicians a readily-accessible and cost-effective alternative to traditional wound care approaches, ultimately enhancing patient care and quality of life.This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
PB Elsevier
YR 2024
FD 2024
LK https://hdl.handle.net/10630/35827
UL https://hdl.handle.net/10630/35827
LA eng
NO Maria Ruiz-Muñoz, Francisco-Javier Martinez-Barrios, Eva Lopezosa-Reca, Placenta-derived biomaterials vs. standard care in chronic diabetic foot ulcer healing: A systematic review and meta-analysis, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Volume 19, Issue 1, 2025, 103170, ISSN 1871-4021, https://doi.org/10.1016/j.dsx.2024.103170
NO Funding for open access charge: Universidad de Málaga / CBUA
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026