RT Generic
T1 Dataset for: "Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory"
A1 Ladrón de Guevara-Miranda, David
A1 Moreno Fernandez, Roman Dario
A1 Gil Rodríguez, Sara
A1 Rosell-Valle, Cristina
A1 Estivill-Torrús, Guillermo
A1 Serrano, Antonia
A1 Pavón, Francisco Javier
A1 Rodriguez-de-Fonseca, Fernando
A1 Santín-Núñez, Luis Javier
A1 Castilla-Ortega, María Estela
K1 Neurobiología del desarrollo
AB Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy because the addition of new neurons may not only facilitate new learning but also modify previous connections and weaken retrograde memories. To investigate whether increasing AHN prompted the forgetting of previous contextual cocaine associations, mice trained in a cocaine-induced conditioned place preference (CPP) paradigm were administered chronic intracerebroventricular infusions of lysophosphatidic acid (LPA, an endogenous lysophospholipid with pro-neurogenic actions), ki16425 (an LPA1/3 receptor antagonist) or a vehicle solution, and they were tested 23 days later for CPP retention and extinction. The results of immunohistochemical experiments showed that the LPA-treated mice exhibited reduced long-term CPP retention and an approximately twofold increase in the number of adult-born hippocampal cells that differentiated into mature neurons. Importantly, mediation analyses confirmed a causal role of AHN in reducing CPP maintenance. In contrast, the ki16425-treated mice displayed aberrant responses, with initially decreased CPP retention that progressively increased across the extinction sessions, leading to no effect on AHN. The pharmacological treatments did not affect locomotion or general exploratory or anxiety-like responses. In a second experiment, normal and LPA1 -receptor-deficient mice were acutely infused with LPA, which revealed that LPA1 -mediated signaling was required for LPA-induced proliferative actions. These results suggest that the LPA/LPA1 pathway acts as a potent in vivo modulator of AHN and highlight the potential usefulness of pro-AHN strategies to treat aberrant cognition in those addicted to cocaine.
PB Universidad de Málaga
YR 2024
FD 2024-01-24
LK https://hdl.handle.net/10630/36922
UL https://hdl.handle.net/10630/36922
LA eng
NO Ladrón de Guevara-Miranda, D., Moreno-Fernández, R. D., Gil-Rodríguez, S., Rosell-Valle, C., Estivill-Torrús, G., Serrano, A., Pavón, F. J., Rodríguez de Fonseca, F., Santín, L. J., & Castilla-Ortega, E. (2019). Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory. Addiction biology, 24(3), 458–470. https://doi.org/10.1111/adb.12612
NO This study was funded by grants from the Spanish Ministry of Economy and Competitiveness (Agencia Estatal de Investigación), which is co-funded by the European Research Development Fund (AEI/FEDER, UE) (PSI2013-44901-P and PSI2017-82604-R to L.J.S. andPSI2015-73156-JIN to E.C.O.); by the National System of Health-Instituto de Salud Carlos III, which is co-funded by AEI/FEDER, UE (Red de Trastornos Adictivos; RD16/0017/0001 to F.R.d.F.); and by the Andalusian R&D&I Programme, Regional Ministry of Economy andKnowledge (PAIDI CTS643 to G.E.T.).
DS RIUMA. Repositorio Institucional de la Universidad de Málaga
RD 19 ene 2026